Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats
This study is aimed to evaluate anti-ulcerogenic effect of ethanolic extract of Acanthopanax trifoliatus leaves (EAT) in acute ulcer induced by absolute ethanol and NSAID (diclofenac) in male Sprague-Dawley (SD) rats and to determine the possible involvement of either suflhydryl group or nitric oxid...
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| Format: | Article |
| Language: | English |
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Società Italo-Latinoamericana di Etnomedicina
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14849/1/Gastroprotective%20effect%20of%20Acanthopanax%20trifoliatus%20on%20experimentally%20induced%20acute%20ulcer%20in%20rats.pdf |
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| author | Abd Hamid @ Abdul Razak, Roslida Hamzah, Siti Nurusaadah Othman, Fezah |
| author_facet | Abd Hamid @ Abdul Razak, Roslida Hamzah, Siti Nurusaadah Othman, Fezah |
| author_sort | Abd Hamid @ Abdul Razak, Roslida |
| collection | UPM |
| description | This study is aimed to evaluate anti-ulcerogenic effect of ethanolic extract of Acanthopanax trifoliatus leaves (EAT) in acute ulcer induced by absolute ethanol and NSAID (diclofenac) in male Sprague-Dawley (SD) rats and to determine the possible involvement of either suflhydryl group or nitric oxide group in it's pathway. The result of the preliminary study showed that EAT did not give any ulcerogenic effect in the rat's stomach. For the gastroprotective study, EAT was shown to have substantial gastroprotective effect on the gastric mucosa of SD rats induced by absolute ethanol at dose 300 mg/kg with a tendency for the activity to be comparable to the standard drug, lansoprazole. Whereas for ulcer induced by NSAID (diclofenac), the extract does not seem to have a significant gastroprotective activity at the dosages used. Investigation of the possible mechanism behind the anti-ulcerogenic activity of the EAT was done using L-NAME (a NO synthase inhibitor) and NEM (a sulfhydryl blocker) in ethanol-induced ulcer models pre-treated with EAT at higher dose (500mg/kg). The previous administration of L-NAME did not reduce the anti-ulcerogenic activity of EAT in ethanol induced ulcer model, suggesting that the pharmacological mechanism has no relationship with NO. On the other hand, pre-treatment with NEM reduced the anti-ulcerogenic activity of EAT on ethanol induced-ulcer model. This result suggests that EAT has active substances that increase the mucosal non-protein sulfhydryl groups which contribute.to the extract's gastroprotective effect. |
| first_indexed | 2024-03-06T07:32:36Z |
| format | Article |
| id | upm.eprints-14849 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:32:36Z |
| publishDate | 2010 |
| publisher | Società Italo-Latinoamericana di Etnomedicina |
| record_format | dspace |
| spelling | upm.eprints-148492016-10-28T04:34:33Z http://psasir.upm.edu.my/id/eprint/14849/ Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats Abd Hamid @ Abdul Razak, Roslida Hamzah, Siti Nurusaadah Othman, Fezah This study is aimed to evaluate anti-ulcerogenic effect of ethanolic extract of Acanthopanax trifoliatus leaves (EAT) in acute ulcer induced by absolute ethanol and NSAID (diclofenac) in male Sprague-Dawley (SD) rats and to determine the possible involvement of either suflhydryl group or nitric oxide group in it's pathway. The result of the preliminary study showed that EAT did not give any ulcerogenic effect in the rat's stomach. For the gastroprotective study, EAT was shown to have substantial gastroprotective effect on the gastric mucosa of SD rats induced by absolute ethanol at dose 300 mg/kg with a tendency for the activity to be comparable to the standard drug, lansoprazole. Whereas for ulcer induced by NSAID (diclofenac), the extract does not seem to have a significant gastroprotective activity at the dosages used. Investigation of the possible mechanism behind the anti-ulcerogenic activity of the EAT was done using L-NAME (a NO synthase inhibitor) and NEM (a sulfhydryl blocker) in ethanol-induced ulcer models pre-treated with EAT at higher dose (500mg/kg). The previous administration of L-NAME did not reduce the anti-ulcerogenic activity of EAT in ethanol induced ulcer model, suggesting that the pharmacological mechanism has no relationship with NO. On the other hand, pre-treatment with NEM reduced the anti-ulcerogenic activity of EAT on ethanol induced-ulcer model. This result suggests that EAT has active substances that increase the mucosal non-protein sulfhydryl groups which contribute.to the extract's gastroprotective effect. Società Italo-Latinoamericana di Etnomedicina 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14849/1/Gastroprotective%20effect%20of%20Acanthopanax%20trifoliatus%20on%20experimentally%20induced%20acute%20ulcer%20in%20rats.pdf Abd Hamid @ Abdul Razak, Roslida and Hamzah, Siti Nurusaadah and Othman, Fezah (2010) Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats. Pharmacologyonline, 2. pp. 828-841. ISSN 1827-8620 http://pharmacologyonline.silae.it/front/archives_2010_2 |
| spellingShingle | Abd Hamid @ Abdul Razak, Roslida Hamzah, Siti Nurusaadah Othman, Fezah Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats |
| title | Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats |
| title_full | Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats |
| title_fullStr | Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats |
| title_full_unstemmed | Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats |
| title_short | Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats |
| title_sort | gastroprotective effect of acanthopanax trifoliatus on experimentally induced acute ulcer in rats |
| url | http://psasir.upm.edu.my/id/eprint/14849/1/Gastroprotective%20effect%20of%20Acanthopanax%20trifoliatus%20on%20experimentally%20induced%20acute%20ulcer%20in%20rats.pdf |
| work_keys_str_mv | AT abdhamidabdulrazakroslida gastroprotectiveeffectofacanthopanaxtrifoliatusonexperimentallyinducedacuteulcerinrats AT hamzahsitinurusaadah gastroprotectiveeffectofacanthopanaxtrifoliatusonexperimentallyinducedacuteulcerinrats AT othmanfezah gastroprotectiveeffectofacanthopanaxtrifoliatusonexperimentallyinducedacuteulcerinrats |