Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet.
In this study, the immunomodulatory effects of zerumbone isolated from Zingiber zerumbet were investigated by evaluating the effects of this compound towards the lymphocytes proliferation (mice thymocytes, mice splenocytes and human human peripheral blood mononuclear cells, PBMC), cell cycle progres...
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| Format: | Article |
| Language: | English English |
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University of Karachi. Faculty of Pharmacy
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15101/1/Immunomodulatory%20effects%20of%20zerumbone%20isolated%20from%20roots%20of%20Zingiber%20zerumbet.pdf |
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| author | Keong, Yeap Swee Mohamed Alitheen, Noorjahan Banu Mustafa, Shuhaimi Abd Aziz, Suraini Abdul Rahman, Mashitoh Ali, Abdul Manaf |
| author_facet | Keong, Yeap Swee Mohamed Alitheen, Noorjahan Banu Mustafa, Shuhaimi Abd Aziz, Suraini Abdul Rahman, Mashitoh Ali, Abdul Manaf |
| author_sort | Keong, Yeap Swee |
| collection | UPM |
| description | In this study, the immunomodulatory effects of zerumbone isolated from Zingiber zerumbet were investigated by evaluating the effects of this compound towards the lymphocytes proliferation (mice thymocytes, mice splenocytes and human human peripheral blood mononuclear cells, PBMC), cell cycle progression and cytokine (interleukin 2 and 12) induction. Lymphocyte proliferation assay showed that zerumbone was able to activate mice thymocytes, splenocytes and PBMC at dosage dependent pattern where the best concentration was 7.5 microg/ml. Flow cytometry analysis showed the highest population of PBMC entered into G2/M phase after treatment for 72 h with 7.5 microg/ml zerumbone. The production of human interleukin-2 and human interleukin-12 cytokines in culture supernatant from zerumbone activated lymphocytes was prominently upregulated at 24 hour and decreased from 48 h to 72 h. The above results indicate that zerumbone can be used as immunomodulatory agent which can react toward the immune cell cytokine production in dosage dependent pattern. |
| first_indexed | 2024-03-06T07:33:21Z |
| format | Article |
| id | upm.eprints-15101 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:33:21Z |
| publishDate | 2010 |
| publisher | University of Karachi. Faculty of Pharmacy |
| record_format | dspace |
| spelling | upm.eprints-151012015-09-22T07:40:00Z http://psasir.upm.edu.my/id/eprint/15101/ Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. Keong, Yeap Swee Mohamed Alitheen, Noorjahan Banu Mustafa, Shuhaimi Abd Aziz, Suraini Abdul Rahman, Mashitoh Ali, Abdul Manaf In this study, the immunomodulatory effects of zerumbone isolated from Zingiber zerumbet were investigated by evaluating the effects of this compound towards the lymphocytes proliferation (mice thymocytes, mice splenocytes and human human peripheral blood mononuclear cells, PBMC), cell cycle progression and cytokine (interleukin 2 and 12) induction. Lymphocyte proliferation assay showed that zerumbone was able to activate mice thymocytes, splenocytes and PBMC at dosage dependent pattern where the best concentration was 7.5 microg/ml. Flow cytometry analysis showed the highest population of PBMC entered into G2/M phase after treatment for 72 h with 7.5 microg/ml zerumbone. The production of human interleukin-2 and human interleukin-12 cytokines in culture supernatant from zerumbone activated lymphocytes was prominently upregulated at 24 hour and decreased from 48 h to 72 h. The above results indicate that zerumbone can be used as immunomodulatory agent which can react toward the immune cell cytokine production in dosage dependent pattern. University of Karachi. Faculty of Pharmacy 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15101/1/Immunomodulatory%20effects%20of%20zerumbone%20isolated%20from%20roots%20of%20Zingiber%20zerumbet.pdf Keong, Yeap Swee and Mohamed Alitheen, Noorjahan Banu and Mustafa, Shuhaimi and Abd Aziz, Suraini and Abdul Rahman, Mashitoh and Ali, Abdul Manaf (2010) Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. Pakistan Journal of Pharmaceutical Sciences, 23 (1). pp. 75-82. ISSN 1011-601X http://www.pjps.pk/CD-PJPS-23-1-10/Paper-13.pdf English |
| spellingShingle | Keong, Yeap Swee Mohamed Alitheen, Noorjahan Banu Mustafa, Shuhaimi Abd Aziz, Suraini Abdul Rahman, Mashitoh Ali, Abdul Manaf Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. |
| title | Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. |
| title_full | Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. |
| title_fullStr | Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. |
| title_full_unstemmed | Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. |
| title_short | Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. |
| title_sort | immunomodulatory effects of zerumbone isolated from roots of zingiber zerumbet |
| url | http://psasir.upm.edu.my/id/eprint/15101/1/Immunomodulatory%20effects%20of%20zerumbone%20isolated%20from%20roots%20of%20Zingiber%20zerumbet.pdf |
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