In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi
Dermatophytes are fungi capable of invading keratinized tissues of humans and animals, causingdermatomycosis. Azole antifungal drugs are often used in the treatment of dermatomycosis. Because ofincreased use of these medications, azoles are known to cause drug resistance; hence this studyinvestigate...
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| Format: | Article |
| Language: | English |
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Academic Journals
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15157/1/15157.pdf |
| _version_ | 1796968789974188032 |
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| author | Aala, Farzad Yusuf, Umi Kalsom Khodavandi, Alireza Jamal, Farida Fatema @ Farida |
| author_facet | Aala, Farzad Yusuf, Umi Kalsom Khodavandi, Alireza Jamal, Farida Fatema @ Farida |
| author_sort | Aala, Farzad |
| collection | UPM |
| description | Dermatophytes are fungi capable of invading keratinized tissues of humans and animals, causingdermatomycosis. Azole antifungal drugs are often used in the treatment of dermatomycosis. Because ofincreased use of these medications, azoles are known to cause drug resistance; hence this studyinvestigated an alternative anti-dermatophyte which is plant-based, and biodegradable natural product.Allicin is a pure bioactive compound derived from garlic, which is known worldwide for its antifungalactivities. This study evaluated thein vitro efficacy of pure allicin alone against six dermatophyteisolates and the MIC50 and MIC90 ranged from 0.098 – 25.0 µg/ml. Results of this study showed that theorder of efficacy based on the MICs values was fluconazole > allicin > ketoconazole at 28ºC for both 7and 10 days incubation. On the other side, most of tested drug combinations demonstrated synergisticor additive interaction for all isolates for both 7 and 10 days incubation at 28ºC. In conclusion allicinalone showed very good potential as an antifungal compound against mycoses-causingdermatophytes, performing better than the synthetic drug fluconazole, and almost the same asketoconazole, furthermore allicin in combination with ketoconazole or with fluconazole frequentlyshowed synergistic or additive interaction against dermatomycosis. |
| first_indexed | 2024-03-06T07:33:31Z |
| format | Article |
| id | upm.eprints-15157 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:33:31Z |
| publishDate | 2010 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | upm.eprints-151572017-11-17T03:12:56Z http://psasir.upm.edu.my/id/eprint/15157/ In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi Aala, Farzad Yusuf, Umi Kalsom Khodavandi, Alireza Jamal, Farida Fatema @ Farida Dermatophytes are fungi capable of invading keratinized tissues of humans and animals, causingdermatomycosis. Azole antifungal drugs are often used in the treatment of dermatomycosis. Because ofincreased use of these medications, azoles are known to cause drug resistance; hence this studyinvestigated an alternative anti-dermatophyte which is plant-based, and biodegradable natural product.Allicin is a pure bioactive compound derived from garlic, which is known worldwide for its antifungalactivities. This study evaluated thein vitro efficacy of pure allicin alone against six dermatophyteisolates and the MIC50 and MIC90 ranged from 0.098 – 25.0 µg/ml. Results of this study showed that theorder of efficacy based on the MICs values was fluconazole > allicin > ketoconazole at 28ºC for both 7and 10 days incubation. On the other side, most of tested drug combinations demonstrated synergisticor additive interaction for all isolates for both 7 and 10 days incubation at 28ºC. In conclusion allicinalone showed very good potential as an antifungal compound against mycoses-causingdermatophytes, performing better than the synthetic drug fluconazole, and almost the same asketoconazole, furthermore allicin in combination with ketoconazole or with fluconazole frequentlyshowed synergistic or additive interaction against dermatomycosis. Academic Journals 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15157/1/15157.pdf Aala, Farzad and Yusuf, Umi Kalsom and Khodavandi, Alireza and Jamal, Farida Fatema @ Farida (2010) In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi. African Journal of Microbiology Research, 4 (5). art. no. E98ADE911928. pp. 380-385. ISSN 1996-0808 http://www.academicjournals.org/journal/AJMR/article-abstract/E98ADE911928 |
| spellingShingle | Aala, Farzad Yusuf, Umi Kalsom Khodavandi, Alireza Jamal, Farida Fatema @ Farida In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi |
| title | In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi |
| title_full | In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi |
| title_fullStr | In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi |
| title_full_unstemmed | In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi |
| title_short | In vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi |
| title_sort | in vitro antifungal activity of allicin alone and in combination with two medications against six dermatophytic fungi |
| url | http://psasir.upm.edu.my/id/eprint/15157/1/15157.pdf |
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