Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes.
The aim of this study was to investigat the lipid peroxidation of plasma as a marker of oxidant-induced protein damage the effects of oxygen radicals on glycated-hemoglobin and to find out the relationship between the increase level of Malondialdehyde (MDA) on HbA1C, lipid profiles and FBS (Fasting...
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| Format: | Article |
| Language: | English English |
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EuroJournals
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15294/1/Investigation%20of%20lipid%20profiles%20and%20lipid%20peroxidation%20in%20patients%20with%20type%202%20diabetes.pdf |
| _version_ | 1825945592913723392 |
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| author | Hanachi, Parichehr Moghadam, Rashid Haydari Abd Latiff, Latiffah |
| author_facet | Hanachi, Parichehr Moghadam, Rashid Haydari Abd Latiff, Latiffah |
| author_sort | Hanachi, Parichehr |
| collection | UPM |
| description | The aim of this study was to investigat the lipid peroxidation of plasma as a marker of oxidant-induced protein damage the effects of oxygen radicals on glycated-hemoglobin and to find out the relationship between the increase level of Malondialdehyde (MDA) on HbA1C, lipid profiles and FBS (Fasting Blood Sugar) in patients with type 2 diabetes. This randomized study included 200 individuals, 100 cases had history of diabetic for at least 3 years (file in Isfehan hospital, Diabetic Center of Medical Sciences University) and 100 cases as the control group without history of diabetes. In both groups, level of MDA, FBS, lipid profiles and HbA1C were determined in fasting blood samples. Results showed that MDA level in diabetic patients was significantly (p<0.005) higher (0.9222 ± 0.3 μmol/L) than those in the control group (0.7428 ± 0.04μmol/L). The same was also true (p<0.05) for the level of HbA1C (9.387 ± 2.4 mg/dl in diabetic patients and 7.356 ± 1.0 mg/dl in the control group) and the FBS (163.31 ± 56mg/dl in patient group and 85.740 ± 10.1 in the control group). Furthermore, the concentration of, LDL significantly was higher (p<0.05) and the HDL level were significantly lower (p<0.05) in case group as compared to control group. The increased plasma lipid peroxidation and decreased plasma HDL that we observed in patients with type 2 diabetes mellitus indicated that these may predispose to the development of cardiovascular complications. |
| first_indexed | 2024-03-06T07:33:55Z |
| format | Article |
| id | upm.eprints-15294 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:33:55Z |
| publishDate | 2009 |
| publisher | EuroJournals |
| record_format | dspace |
| spelling | upm.eprints-152942015-09-15T04:28:52Z http://psasir.upm.edu.my/id/eprint/15294/ Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. Hanachi, Parichehr Moghadam, Rashid Haydari Abd Latiff, Latiffah The aim of this study was to investigat the lipid peroxidation of plasma as a marker of oxidant-induced protein damage the effects of oxygen radicals on glycated-hemoglobin and to find out the relationship between the increase level of Malondialdehyde (MDA) on HbA1C, lipid profiles and FBS (Fasting Blood Sugar) in patients with type 2 diabetes. This randomized study included 200 individuals, 100 cases had history of diabetic for at least 3 years (file in Isfehan hospital, Diabetic Center of Medical Sciences University) and 100 cases as the control group without history of diabetes. In both groups, level of MDA, FBS, lipid profiles and HbA1C were determined in fasting blood samples. Results showed that MDA level in diabetic patients was significantly (p<0.005) higher (0.9222 ± 0.3 μmol/L) than those in the control group (0.7428 ± 0.04μmol/L). The same was also true (p<0.05) for the level of HbA1C (9.387 ± 2.4 mg/dl in diabetic patients and 7.356 ± 1.0 mg/dl in the control group) and the FBS (163.31 ± 56mg/dl in patient group and 85.740 ± 10.1 in the control group). Furthermore, the concentration of, LDL significantly was higher (p<0.05) and the HDL level were significantly lower (p<0.05) in case group as compared to control group. The increased plasma lipid peroxidation and decreased plasma HDL that we observed in patients with type 2 diabetes mellitus indicated that these may predispose to the development of cardiovascular complications. EuroJournals 2009-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15294/1/Investigation%20of%20lipid%20profiles%20and%20lipid%20peroxidation%20in%20patients%20with%20type%202%20diabetes.pdf Hanachi, Parichehr and Moghadam, Rashid Haydari and Abd Latiff, Latiffah (2009) Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. European Journal of Scientific Research, 28 (1). pp. 6-13. ISSN 1450-216X, ESSN: 1450-202X http://www.europeanjournalofscientificresearch.com/ English |
| spellingShingle | Hanachi, Parichehr Moghadam, Rashid Haydari Abd Latiff, Latiffah Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. |
| title | Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. |
| title_full | Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. |
| title_fullStr | Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. |
| title_full_unstemmed | Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. |
| title_short | Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. |
| title_sort | investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes |
| url | http://psasir.upm.edu.my/id/eprint/15294/1/Investigation%20of%20lipid%20profiles%20and%20lipid%20peroxidation%20in%20patients%20with%20type%202%20diabetes.pdf |
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