Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest
We have previously shown that mesenchymal stem cells (MSC) inhibit tumour cell proliferation, thus promising a novel therapy for treating cancers. In this study, MSC were generated from human bone marrow samples and characterised based on standard immunophenotyping. When MSC were co-cultured with BV...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15613/1/Mesenchymal%20stem%20cells%20inhibit%20proliferation%20of%20lymphoid%20origin%20haematopoietic%20tumour%20cells%20by%20inducing%20cell%20cycle%20arrest.pdf |
| _version_ | 1825945654924410880 |
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| author | Sarmadi, Vahid Hosseinpour Tong, Chih Kong Vidyadaran, Sharmili Abdullah, Maha Seow, Heng Fong Ramasamy, Rajesh |
| author_facet | Sarmadi, Vahid Hosseinpour Tong, Chih Kong Vidyadaran, Sharmili Abdullah, Maha Seow, Heng Fong Ramasamy, Rajesh |
| author_sort | Sarmadi, Vahid Hosseinpour |
| collection | UPM |
| description | We have previously shown that mesenchymal stem cells (MSC) inhibit tumour cell proliferation, thus promising a novel therapy for treating cancers. In this study, MSC were generated from human bone marrow samples and characterised based on standard immunophenotyping. When MSC were co-cultured with BV173 and Jurkat tumour cells, the proliferation of tumour cells were profoundly inhibited in a dose dependent manner mainly via cell to cell contact interaction. Further cell cycle analysis reveals that MSC arrest tumour cell proliferation in G0/G1 phase of cell cycle thus preventing the entry of tumour cells into S phase of cell cycle. |
| first_indexed | 2024-03-06T07:34:51Z |
| format | Article |
| id | upm.eprints-15613 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:34:51Z |
| publishDate | 2010 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | upm.eprints-156132017-08-09T08:11:49Z http://psasir.upm.edu.my/id/eprint/15613/ Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest Sarmadi, Vahid Hosseinpour Tong, Chih Kong Vidyadaran, Sharmili Abdullah, Maha Seow, Heng Fong Ramasamy, Rajesh We have previously shown that mesenchymal stem cells (MSC) inhibit tumour cell proliferation, thus promising a novel therapy for treating cancers. In this study, MSC were generated from human bone marrow samples and characterised based on standard immunophenotyping. When MSC were co-cultured with BV173 and Jurkat tumour cells, the proliferation of tumour cells were profoundly inhibited in a dose dependent manner mainly via cell to cell contact interaction. Further cell cycle analysis reveals that MSC arrest tumour cell proliferation in G0/G1 phase of cell cycle thus preventing the entry of tumour cells into S phase of cell cycle. Malaysian Medical Association 2010-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15613/1/Mesenchymal%20stem%20cells%20inhibit%20proliferation%20of%20lymphoid%20origin%20haematopoietic%20tumour%20cells%20by%20inducing%20cell%20cycle%20arrest.pdf Sarmadi, Vahid Hosseinpour and Tong, Chih Kong and Vidyadaran, Sharmili and Abdullah, Maha and Seow, Heng Fong and Ramasamy, Rajesh (2010) Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest. Medical Journal of Malaysia, 65 (3). pp. 202-207. ISSN 0300-5283 http://www.e-mjm.org/2010/v65n3/index.html |
| spellingShingle | Sarmadi, Vahid Hosseinpour Tong, Chih Kong Vidyadaran, Sharmili Abdullah, Maha Seow, Heng Fong Ramasamy, Rajesh Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest |
| title | Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest |
| title_full | Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest |
| title_fullStr | Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest |
| title_full_unstemmed | Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest |
| title_short | Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest |
| title_sort | mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest |
| url | http://psasir.upm.edu.my/id/eprint/15613/1/Mesenchymal%20stem%20cells%20inhibit%20proliferation%20of%20lymphoid%20origin%20haematopoietic%20tumour%20cells%20by%20inducing%20cell%20cycle%20arrest.pdf |
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