Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity.
This study investigated the role of antioxidant enzyme system following crude hydroethanolic extract of Moringa oleifera leaves (MO) in acute paracetamol (PCM) induced hepatotoxicity. Hydroethanolic extract (80%) of MO (200 mg/kg and 800 mg/kg; p.o) was pre-administered before a single oral dose of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Nutrition Society of Malaysia
2010
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/15729/1/Moringa%20oleifera%20enhances%20liver%20antioxidant%20status%20via%20elevation%20of%20antioxidant%20enzymes%20activity%20and%20counteracts%20paracetamol.pdf |
| _version_ | 1796968907664261120 |
|---|---|
| author | Nanthini, Uma Fakurazi, Sharida Ithnin, Hairuszah |
| author_facet | Nanthini, Uma Fakurazi, Sharida Ithnin, Hairuszah |
| author_sort | Nanthini, Uma |
| collection | UPM |
| description | This study investigated the role of antioxidant enzyme system following crude hydroethanolic extract of Moringa oleifera leaves (MO) in acute paracetamol (PCM) induced hepatotoxicity. Hydroethanolic extract (80%) of MO (200 mg/kg and 800 mg/kg; p.o) was pre-administered before a single oral dose of 3 g/kg PCM intoxication to male Sprague-Dawley rats. Pre-treatment of the extract was found to have reduced lipid peroxidation level when compared to the group treated with PCM only. The level of glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) was restored to near normal in groups that were pre-treated with MO. Histopathological studies have further confirmed the hepatoprotective activity of MO compared to group treated with PCM only. The results obtained were comparable to silymarin (200 mg/kg; p.o). The MO extract was found to have significantly protected the liver against toxicity following PCM intoxication by enhancing the level of antioxidant enzyme activity.
|
| first_indexed | 2024-03-06T07:35:12Z |
| format | Article |
| id | upm.eprints-15729 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:35:12Z |
| publishDate | 2010 |
| publisher | Nutrition Society of Malaysia |
| record_format | dspace |
| spelling | upm.eprints-157292015-12-16T08:18:28Z http://psasir.upm.edu.my/id/eprint/15729/ Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. Nanthini, Uma Fakurazi, Sharida Ithnin, Hairuszah This study investigated the role of antioxidant enzyme system following crude hydroethanolic extract of Moringa oleifera leaves (MO) in acute paracetamol (PCM) induced hepatotoxicity. Hydroethanolic extract (80%) of MO (200 mg/kg and 800 mg/kg; p.o) was pre-administered before a single oral dose of 3 g/kg PCM intoxication to male Sprague-Dawley rats. Pre-treatment of the extract was found to have reduced lipid peroxidation level when compared to the group treated with PCM only. The level of glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) was restored to near normal in groups that were pre-treated with MO. Histopathological studies have further confirmed the hepatoprotective activity of MO compared to group treated with PCM only. The results obtained were comparable to silymarin (200 mg/kg; p.o). The MO extract was found to have significantly protected the liver against toxicity following PCM intoxication by enhancing the level of antioxidant enzyme activity. Nutrition Society of Malaysia 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15729/1/Moringa%20oleifera%20enhances%20liver%20antioxidant%20status%20via%20elevation%20of%20antioxidant%20enzymes%20activity%20and%20counteracts%20paracetamol.pdf Nanthini, Uma and Fakurazi, Sharida and Ithnin, Hairuszah (2010) Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. Malaysian Journal of Nutrition, 16 (2). pp. 293-307. ISSN 1394-035X English |
| spellingShingle | Nanthini, Uma Fakurazi, Sharida Ithnin, Hairuszah Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. |
| title | Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. |
| title_full | Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. |
| title_fullStr | Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. |
| title_full_unstemmed | Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. |
| title_short | Moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol-induced hepatotoxicity. |
| title_sort | moringa oleifera enhances liver antioxidant status via elevation of antioxidant enzymes activity and counteracts paracetamol induced hepatotoxicity |
| url | http://psasir.upm.edu.my/id/eprint/15729/1/Moringa%20oleifera%20enhances%20liver%20antioxidant%20status%20via%20elevation%20of%20antioxidant%20enzymes%20activity%20and%20counteracts%20paracetamol.pdf |
| work_keys_str_mv | AT nanthiniuma moringaoleiferaenhancesliverantioxidantstatusviaelevationofantioxidantenzymesactivityandcounteractsparacetamolinducedhepatotoxicity AT fakurazisharida moringaoleiferaenhancesliverantioxidantstatusviaelevationofantioxidantenzymesactivityandcounteractsparacetamolinducedhepatotoxicity AT ithninhairuszah moringaoleiferaenhancesliverantioxidantstatusviaelevationofantioxidantenzymesactivityandcounteractsparacetamolinducedhepatotoxicity |