No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia.
The presence of a dimorphic BglI site in the first intron of the Renin (REN) gene is an increased risk in essential hypertension. Several studies have found the association between BglI dimorphism and essential hypertension with conflicting results in various populations, which might be due to ethni...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Medwell Publishing.
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15816/1/No%20association%20of%20BgII%20dimorphism%20of%20human%20renin%20gene%20in%20hypertensive%20subjects%20in%20Malaysia.pdf |
| _version_ | 1825945694681169920 |
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| author | Vasudevan, R Ismail , Patimah Stanslas, Johnson Shamsudin, Norashikin |
| author_facet | Vasudevan, R Ismail , Patimah Stanslas, Johnson Shamsudin, Norashikin |
| author_sort | Vasudevan, R |
| collection | UPM |
| description | The presence of a dimorphic BglI site in the first intron of the Renin (REN) gene is an increased risk in essential hypertension. Several studies have found the association between BglI dimorphism and essential hypertension with conflicting results in various populations, which might be due to ethnic and geographical variations. The objective of this study is to determine the relationship between the BglI dimorphism of REN gene and Essential Hypertension (EHT) with or without Type 2 Diabetes Mellitus (T2DM) in Malaysian subjects. The study includes 70 EHT, 60 EHT with T2DM and 70 unrelated healthy subjects from the three ethnic groups of Malaysian Subjects. The genotype of BglI dimorphism was done by PCR-RFLP method using BglI restriction enzyme. The frequency of the BglI (+) allele was 37.86% in EHT, 40.83% in EHT with T2DM subjects and 35.71% in control subjects. The results of this study indicate that the BglI (+) allele of REN gene is not associated with essential hypertension with or without T2DM in Malaysian Subjects.
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| first_indexed | 2024-03-06T07:35:28Z |
| format | Article |
| id | upm.eprints-15816 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:35:28Z |
| publishDate | 2008 |
| publisher | Medwell Publishing. |
| record_format | dspace |
| spelling | upm.eprints-158162015-10-08T02:54:53Z http://psasir.upm.edu.my/id/eprint/15816/ No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. Vasudevan, R Ismail , Patimah Stanslas, Johnson Shamsudin, Norashikin The presence of a dimorphic BglI site in the first intron of the Renin (REN) gene is an increased risk in essential hypertension. Several studies have found the association between BglI dimorphism and essential hypertension with conflicting results in various populations, which might be due to ethnic and geographical variations. The objective of this study is to determine the relationship between the BglI dimorphism of REN gene and Essential Hypertension (EHT) with or without Type 2 Diabetes Mellitus (T2DM) in Malaysian subjects. The study includes 70 EHT, 60 EHT with T2DM and 70 unrelated healthy subjects from the three ethnic groups of Malaysian Subjects. The genotype of BglI dimorphism was done by PCR-RFLP method using BglI restriction enzyme. The frequency of the BglI (+) allele was 37.86% in EHT, 40.83% in EHT with T2DM subjects and 35.71% in control subjects. The results of this study indicate that the BglI (+) allele of REN gene is not associated with essential hypertension with or without T2DM in Malaysian Subjects. Medwell Publishing. 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15816/1/No%20association%20of%20BgII%20dimorphism%20of%20human%20renin%20gene%20in%20hypertensive%20subjects%20in%20Malaysia.pdf Vasudevan, R and Ismail , Patimah and Stanslas, Johnson and Shamsudin, Norashikin (2008) No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. Research Journal of Biological Sciences, 3 (10). pp. 1218-1222. ISSN 1815-8846, ESSN: 1993-6087 http://www.medwelljournals.com English |
| spellingShingle | Vasudevan, R Ismail , Patimah Stanslas, Johnson Shamsudin, Norashikin No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. |
| title | No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. |
| title_full | No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. |
| title_fullStr | No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. |
| title_full_unstemmed | No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. |
| title_short | No association of BgII dimorphism of human renin gene in hypertensive subjects in Malaysia. |
| title_sort | no association of bgii dimorphism of human renin gene in hypertensive subjects in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/15816/1/No%20association%20of%20BgII%20dimorphism%20of%20human%20renin%20gene%20in%20hypertensive%20subjects%20in%20Malaysia.pdf |
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