Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats
Orthosiphon stamineus Benth., which is used as a gastroprotective herbal remedy in Malaysia, was assessed for its anti-ulcerogenic activity against ethanol-induced ulcers in rats. Fifty percent methanol was used to extract the oven-dried O. stamineus leaves. The extract was then lyophilized with a r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16010/1/Orthosiphon%20stamineus%20leaf%20extract%20protects%20against%20ethanol.pdf |
| _version_ | 1825945732806344704 |
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| author | Yam, Mun Fei Ang, Lee Fung Salman, Ibrahim Muhammad Ameer, Omar Ziad Lim, Vuanghao Ong, Lai Man Ahmad, Mariam Asmawil, Mohd Zaini Basir, Rusliza |
| author_facet | Yam, Mun Fei Ang, Lee Fung Salman, Ibrahim Muhammad Ameer, Omar Ziad Lim, Vuanghao Ong, Lai Man Ahmad, Mariam Asmawil, Mohd Zaini Basir, Rusliza |
| author_sort | Yam, Mun Fei |
| collection | UPM |
| description | Orthosiphon stamineus Benth., which is used as a gastroprotective herbal remedy in Malaysia, was assessed for its anti-ulcerogenic activity against ethanol-induced ulcers in rats. Fifty percent methanol was used to extract the oven-dried O. stamineus leaves. The extract was then lyophilized with a rotary evaporator and freeze-dried. Oral administration of O. stamineus methanolic extract (OSME) (125, 250, 500, and 1,000mg/kg) was found to significantly decrease the ulcer index (P<.01, P<.001, P<.001, and P<.001, respectively). Histological study of a section of the rat stomach also showed a marked improvement in the gastric mucosal damage in groups receiving OSME. In order to further investigate the gastroprotective mechanism of OSME, mucus secretion and lipid peroxidation level were estimated in vitro and ex vivo. OSME exhibited dose-dependent stimulation of mucus secretion (r=0.718, P<.001) and inhibition of lipid peroxidation in rat gastric mucosal homogenates (both in vitro [r=0.819, P<.05] and ex vivo [r=0.981, P<.05]). It was concluded that the gastroprotective mechanism of OSME was partly due to its ability to inhibit lipid peroxidation and stimulate gastric mucus secretion. |
| first_indexed | 2024-03-06T07:36:03Z |
| format | Article |
| id | upm.eprints-16010 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:36:03Z |
| publishDate | 2009 |
| publisher | Mary Ann Liebert |
| record_format | dspace |
| spelling | upm.eprints-160102019-11-01T03:38:52Z http://psasir.upm.edu.my/id/eprint/16010/ Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats Yam, Mun Fei Ang, Lee Fung Salman, Ibrahim Muhammad Ameer, Omar Ziad Lim, Vuanghao Ong, Lai Man Ahmad, Mariam Asmawil, Mohd Zaini Basir, Rusliza Orthosiphon stamineus Benth., which is used as a gastroprotective herbal remedy in Malaysia, was assessed for its anti-ulcerogenic activity against ethanol-induced ulcers in rats. Fifty percent methanol was used to extract the oven-dried O. stamineus leaves. The extract was then lyophilized with a rotary evaporator and freeze-dried. Oral administration of O. stamineus methanolic extract (OSME) (125, 250, 500, and 1,000mg/kg) was found to significantly decrease the ulcer index (P<.01, P<.001, P<.001, and P<.001, respectively). Histological study of a section of the rat stomach also showed a marked improvement in the gastric mucosal damage in groups receiving OSME. In order to further investigate the gastroprotective mechanism of OSME, mucus secretion and lipid peroxidation level were estimated in vitro and ex vivo. OSME exhibited dose-dependent stimulation of mucus secretion (r=0.718, P<.001) and inhibition of lipid peroxidation in rat gastric mucosal homogenates (both in vitro [r=0.819, P<.05] and ex vivo [r=0.981, P<.05]). It was concluded that the gastroprotective mechanism of OSME was partly due to its ability to inhibit lipid peroxidation and stimulate gastric mucus secretion. Mary Ann Liebert 2009-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16010/1/Orthosiphon%20stamineus%20leaf%20extract%20protects%20against%20ethanol.pdf Yam, Mun Fei and Ang, Lee Fung and Salman, Ibrahim Muhammad and Ameer, Omar Ziad and Lim, Vuanghao and Ong, Lai Man and Ahmad, Mariam and Asmawil, Mohd Zaini and Basir, Rusliza (2009) Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats. Journal of Medicinal Food, 12 (5). pp. 1089-1097. ISSN 1096-620X; ESSN: 1557-7600 https://www.liebertpub.com/doi/10.1089/jmf.2008.0005 10.1089/jmf.2008.0005 |
| spellingShingle | Yam, Mun Fei Ang, Lee Fung Salman, Ibrahim Muhammad Ameer, Omar Ziad Lim, Vuanghao Ong, Lai Man Ahmad, Mariam Asmawil, Mohd Zaini Basir, Rusliza Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats |
| title | Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats |
| title_full | Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats |
| title_fullStr | Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats |
| title_full_unstemmed | Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats |
| title_short | Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats |
| title_sort | orthosiphon stamineus leaf extract protects against ethanol induced gastropathy in rats |
| url | http://psasir.upm.edu.my/id/eprint/16010/1/Orthosiphon%20stamineus%20leaf%20extract%20protects%20against%20ethanol.pdf |
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