A case of severe Plasmodium knowlesi in a splenectomized patient
Plasmodium knowlesi, a zoonotic malaria, is now considered the fifth species of Plasmodium causing malaria in humans. With its 24-hour erythrocytic stage of development, it has raised concern regarding its high potential in replicating and leading to severe illness. Spleen is an important site for r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16197/1/A%20case%20of%20severe%20Plasmodium%20knowlesi%20in%20a%20splenectomized%20patient.pdf |
| _version_ | 1825945769200320512 |
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| author | Boo, Yang Liang Lim, Hong Tak Chin, Pek Woon Lim, Suat Yee Hoo, Fan Kee |
| author_facet | Boo, Yang Liang Lim, Hong Tak Chin, Pek Woon Lim, Suat Yee Hoo, Fan Kee |
| author_sort | Boo, Yang Liang |
| collection | UPM |
| description | Plasmodium knowlesi, a zoonotic malaria, is now considered the fifth species of Plasmodium causing malaria in humans. With its 24-hour erythrocytic stage of development, it has raised concern regarding its high potential in replicating and leading to severe illness. Spleen is an important site for removal of parasitized red blood cells and generating immunity. We reported a case of knowlesi malaria in a non-immune, splenectomized patient. We observed the delay in parasite clearance, high parasitic counts, and severe illness at presentation. A thorough search through literature revealed several case reports on falciparum and vivax malaria in splenectomized patients. However, literature available for knowlesi malaria in splenectomized patient is limited. Further studies need to be carried out to clarify the role of spleen in host defense against human malaria especially P. knowlesi. |
| first_indexed | 2024-03-06T07:36:37Z |
| format | Article |
| id | upm.eprints-16197 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:36:37Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-161972016-06-08T01:15:20Z http://psasir.upm.edu.my/id/eprint/16197/ A case of severe Plasmodium knowlesi in a splenectomized patient Boo, Yang Liang Lim, Hong Tak Chin, Pek Woon Lim, Suat Yee Hoo, Fan Kee Plasmodium knowlesi, a zoonotic malaria, is now considered the fifth species of Plasmodium causing malaria in humans. With its 24-hour erythrocytic stage of development, it has raised concern regarding its high potential in replicating and leading to severe illness. Spleen is an important site for removal of parasitized red blood cells and generating immunity. We reported a case of knowlesi malaria in a non-immune, splenectomized patient. We observed the delay in parasite clearance, high parasitic counts, and severe illness at presentation. A thorough search through literature revealed several case reports on falciparum and vivax malaria in splenectomized patients. However, literature available for knowlesi malaria in splenectomized patient is limited. Further studies need to be carried out to clarify the role of spleen in host defense against human malaria especially P. knowlesi. Elsevier 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16197/1/A%20case%20of%20severe%20Plasmodium%20knowlesi%20in%20a%20splenectomized%20patient.pdf Boo, Yang Liang and Lim, Hong Tak and Chin, Pek Woon and Lim, Suat Yee and Hoo, Fan Kee (2016) A case of severe Plasmodium knowlesi in a splenectomized patient. Parasitology International, 65 (1). pp. 55-57. ISSN 1383-5769; ESSN: 1873-0329 http://www.sciencedirect.com/science/article/pii/S1383576915001671 10.1016/j.parint.2015.10.003 |
| spellingShingle | Boo, Yang Liang Lim, Hong Tak Chin, Pek Woon Lim, Suat Yee Hoo, Fan Kee A case of severe Plasmodium knowlesi in a splenectomized patient |
| title | A case of severe Plasmodium knowlesi in a splenectomized patient |
| title_full | A case of severe Plasmodium knowlesi in a splenectomized patient |
| title_fullStr | A case of severe Plasmodium knowlesi in a splenectomized patient |
| title_full_unstemmed | A case of severe Plasmodium knowlesi in a splenectomized patient |
| title_short | A case of severe Plasmodium knowlesi in a splenectomized patient |
| title_sort | case of severe plasmodium knowlesi in a splenectomized patient |
| url | http://psasir.upm.edu.my/id/eprint/16197/1/A%20case%20of%20severe%20Plasmodium%20knowlesi%20in%20a%20splenectomized%20patient.pdf |
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