Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2.
This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-wee...
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| Format: | Article |
| Language: | English |
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Springer Science + Business Media B.V.
2006
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| _version_ | 1825945804563546112 |
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| author | Saad, Mohd Zamri Ernie, Z.A. Mohd Yusoff, Sabri |
| author_facet | Saad, Mohd Zamri Ernie, Z.A. Mohd Yusoff, Sabri |
| author_sort | Saad, Mohd Zamri |
| collection | UPM |
| description | This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-week interval, to 7 × 106 cfu/ml of live P. multocida B:2. Goats of group 2 were not exposed to P. multocida B:2 but were kept together with the exposed group 1. Goats of group 3 remained as unexposed controls and were kept separated from the other two groups. Serum samples were collected at weekly intervals to determine the antibody levels. At week 5 post exposure, all goats were challenged subcutaneously with 3.7 × 1010 cfu/ml of live P. multocida B:2. Following challenge exposure, 8 (67%) goats (4 goats from each of groups 1 and 2) were killed owing to haemorrhagic septicaemia. Four goats were killed peracutely within 48 h post challenge, while the other four goats were killed acutely between 2 and 4 days post challenge. None of the goats of group 3 were killed for haemorrhagic septicaemia. Goats of groups 1 and 2 showed significantly (p < 0.05) higher antibody levels following the first intranasal exposure to P. multocida B:2. However, only group 1 retained the significantly (p < 0.05) high antibody levels following a second intranasal exposure, and remained significantly (p<0.05) higher than groups 2 and 3 at the time of challenge. P. multocida B:2 was successfully isolated from various organs of goats that were killed between 1 and 4 days post challenge. |
| first_indexed | 2024-03-06T07:37:15Z |
| format | Article |
| id | upm.eprints-16378 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:37:15Z |
| publishDate | 2006 |
| publisher | Springer Science + Business Media B.V. |
| record_format | dspace |
| spelling | upm.eprints-163782013-11-19T08:42:04Z http://psasir.upm.edu.my/id/eprint/16378/ Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. Saad, Mohd Zamri Ernie, Z.A. Mohd Yusoff, Sabri This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-week interval, to 7 × 106 cfu/ml of live P. multocida B:2. Goats of group 2 were not exposed to P. multocida B:2 but were kept together with the exposed group 1. Goats of group 3 remained as unexposed controls and were kept separated from the other two groups. Serum samples were collected at weekly intervals to determine the antibody levels. At week 5 post exposure, all goats were challenged subcutaneously with 3.7 × 1010 cfu/ml of live P. multocida B:2. Following challenge exposure, 8 (67%) goats (4 goats from each of groups 1 and 2) were killed owing to haemorrhagic septicaemia. Four goats were killed peracutely within 48 h post challenge, while the other four goats were killed acutely between 2 and 4 days post challenge. None of the goats of group 3 were killed for haemorrhagic septicaemia. Goats of groups 1 and 2 showed significantly (p < 0.05) higher antibody levels following the first intranasal exposure to P. multocida B:2. However, only group 1 retained the significantly (p < 0.05) high antibody levels following a second intranasal exposure, and remained significantly (p<0.05) higher than groups 2 and 3 at the time of challenge. P. multocida B:2 was successfully isolated from various organs of goats that were killed between 1 and 4 days post challenge. Springer Science + Business Media B.V. 2006 Article PeerReviewed Saad, Mohd Zamri and Ernie, Z.A. and Mohd Yusoff, Sabri (2006) Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. Tropical Animal Health and Production, 38. pp. 541-546. ISSN 1573-7438 10.1007/s11250-006-4437-x English |
| spellingShingle | Saad, Mohd Zamri Ernie, Z.A. Mohd Yusoff, Sabri Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. |
| title | Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. |
| title_full | Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. |
| title_fullStr | Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. |
| title_full_unstemmed | Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. |
| title_short | Protective effect follwoing intranasal exposure of goats to live Pasteurella multocida b:2. |
| title_sort | protective effect follwoing intranasal exposure of goats to live pasteurella multocida b 2 |
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