Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia
Prostate cancer is ranked fourth among the most prevalent cancers in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. With the emergence of reputable imaging tracers such as fluorine-18-labelled choline (18F-fluorocholine) and gallium-68 label...
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| Format: | Article |
| Language: | English |
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Bentham Science Publishers
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16490/1/Synthesis%20of%20fluorine-18-labelled%20choline%20%2818F-fluorocholine%29%20towards%20an%20early%20and%20accurate%20management%20of%20prostate%20cancer%20in%20Malaysia.pdf |
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| author | Hassan, Muhammad Hishar Abu Bakar, Suharzelim Che A. Halim, Khairul Najah Idris, Jaleezah Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil |
| author_facet | Hassan, Muhammad Hishar Abu Bakar, Suharzelim Che A. Halim, Khairul Najah Idris, Jaleezah Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil |
| author_sort | Hassan, Muhammad Hishar |
| collection | UPM |
| description | Prostate cancer is ranked fourth among the most prevalent cancers in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. With the emergence of reputable imaging tracers such as fluorine-18-labelled choline (18F-fluorocholine) and gallium-68 labelled prostate specific membrane antigen (68Ga-PSMA) for the diagnosis of prostate cancer in positron emission tomography / computed tomography (PET/CT) modality, the challenges in the staging and detection accuracy would promise a better management strategy for patients. This article presents the synthesis of 18F-fluorocholine and a convenient method for quality control analysis of 18F-fluorocholine. In addition, the aim of this research work is to assist local Good Manufacturing Practice (GMP) radiopharmaceutical laboratories that routinely produce 18F-fluorodeoxyglucose (18F-FDG), to start producing 18F-fluorocholine as a tracer for prostate cancer imaging. |
| first_indexed | 2024-03-06T07:37:34Z |
| format | Article |
| id | upm.eprints-16490 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:37:34Z |
| publishDate | 2016 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | upm.eprints-164902016-06-08T01:54:50Z http://psasir.upm.edu.my/id/eprint/16490/ Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia Hassan, Muhammad Hishar Abu Bakar, Suharzelim Che A. Halim, Khairul Najah Idris, Jaleezah Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Prostate cancer is ranked fourth among the most prevalent cancers in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. With the emergence of reputable imaging tracers such as fluorine-18-labelled choline (18F-fluorocholine) and gallium-68 labelled prostate specific membrane antigen (68Ga-PSMA) for the diagnosis of prostate cancer in positron emission tomography / computed tomography (PET/CT) modality, the challenges in the staging and detection accuracy would promise a better management strategy for patients. This article presents the synthesis of 18F-fluorocholine and a convenient method for quality control analysis of 18F-fluorocholine. In addition, the aim of this research work is to assist local Good Manufacturing Practice (GMP) radiopharmaceutical laboratories that routinely produce 18F-fluorodeoxyglucose (18F-FDG), to start producing 18F-fluorocholine as a tracer for prostate cancer imaging. Bentham Science Publishers 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16490/1/Synthesis%20of%20fluorine-18-labelled%20choline%20%2818F-fluorocholine%29%20towards%20an%20early%20and%20accurate%20management%20of%20prostate%20cancer%20in%20Malaysia.pdf Hassan, Muhammad Hishar and Abu Bakar, Suharzelim and Che A. Halim, Khairul Najah and Idris, Jaleezah and Ahmad Saad, Fathinul Fikri and Nordin, Abdul Jalil (2016) Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia. Current Medical Imaging Reviews, 12 (1). pp. 67-74. ISSN 1573-4056; ESSN: 1875-6603 http://benthamscience.com/journals/current-medical-imaging-reviews/volume/12/issue/1/page/67/ 10.2174/1573405612666151203203739 |
| spellingShingle | Hassan, Muhammad Hishar Abu Bakar, Suharzelim Che A. Halim, Khairul Najah Idris, Jaleezah Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia |
| title | Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia |
| title_full | Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia |
| title_fullStr | Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia |
| title_full_unstemmed | Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia |
| title_short | Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia |
| title_sort | synthesis of fluorine 18 labelled choline 18f fluorocholine towards an early and accurate management of prostate cancer in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/16490/1/Synthesis%20of%20fluorine-18-labelled%20choline%20%2818F-fluorocholine%29%20towards%20an%20early%20and%20accurate%20management%20of%20prostate%20cancer%20in%20Malaysia.pdf |
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