Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99
A 13 year old boy presented with a huge mass on his right arm of 6 months duration. Histopathological examination revealed sheets of malignant small round blue cells with immunopositivity for LCA, CD43, CD45Ro, CD30, EMA, ALK-1 and CD99, and negativity for CD20, TdT, myogenin, myoD1, NSE, bcl-6, bcl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Medical Association
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16740/1/Small%20cell%20variant%20of%20anaplastic%20large%20cell%20lymphoma%20with%20positive%20immunoreactivity%20for%20CD99.pdf |
| _version_ | 1825945874236178432 |
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| author | Mohd Sidik, Shiran Tan, Geok Chin Abdul Rahman, Sabariah Chye, P. C. Pathmanathan, Rajadurai |
| author_facet | Mohd Sidik, Shiran Tan, Geok Chin Abdul Rahman, Sabariah Chye, P. C. Pathmanathan, Rajadurai |
| author_sort | Mohd Sidik, Shiran |
| collection | UPM |
| description | A 13 year old boy presented with a huge mass on his right arm of 6 months duration. Histopathological examination revealed sheets of malignant small round blue cells with immunopositivity for LCA, CD43, CD45Ro, CD30, EMA, ALK-1 and CD99, and negativity for CD20, TdT, myogenin, myoD1, NSE, bcl-6, bcl-2 and CD10. Fluorescent In-Situ Hybridization (FISH) testing excluded the diagnosis of Ewing's sarcoma/ PNET. Pathologists need to be aware of the diagnosis of a small cell variant of ALCL, as well as of the fact that CD99 expression commonly occurs in cases of ALK-positive ALCL, in order to distinguish this entity from Ewing's sarcoma/PNET. |
| first_indexed | 2024-03-06T07:38:19Z |
| format | Article |
| id | upm.eprints-16740 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:38:19Z |
| publishDate | 2008 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | upm.eprints-167402018-01-15T09:24:16Z http://psasir.upm.edu.my/id/eprint/16740/ Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99 Mohd Sidik, Shiran Tan, Geok Chin Abdul Rahman, Sabariah Chye, P. C. Pathmanathan, Rajadurai A 13 year old boy presented with a huge mass on his right arm of 6 months duration. Histopathological examination revealed sheets of malignant small round blue cells with immunopositivity for LCA, CD43, CD45Ro, CD30, EMA, ALK-1 and CD99, and negativity for CD20, TdT, myogenin, myoD1, NSE, bcl-6, bcl-2 and CD10. Fluorescent In-Situ Hybridization (FISH) testing excluded the diagnosis of Ewing's sarcoma/ PNET. Pathologists need to be aware of the diagnosis of a small cell variant of ALCL, as well as of the fact that CD99 expression commonly occurs in cases of ALK-positive ALCL, in order to distinguish this entity from Ewing's sarcoma/PNET. Malaysian Medical Association 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16740/1/Small%20cell%20variant%20of%20anaplastic%20large%20cell%20lymphoma%20with%20positive%20immunoreactivity%20for%20CD99.pdf Mohd Sidik, Shiran and Tan, Geok Chin and Abdul Rahman, Sabariah and Chye, P. C. and Pathmanathan, Rajadurai (2008) Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99. Medical Journal of Malaysia, 63 (2). pp. 150-151. ISSN 0300-5283 http://www.e-mjm.org/2008/v63n2/index.html |
| spellingShingle | Mohd Sidik, Shiran Tan, Geok Chin Abdul Rahman, Sabariah Chye, P. C. Pathmanathan, Rajadurai Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99 |
| title | Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99 |
| title_full | Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99 |
| title_fullStr | Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99 |
| title_full_unstemmed | Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99 |
| title_short | Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99 |
| title_sort | small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for cd99 |
| url | http://psasir.upm.edu.my/id/eprint/16740/1/Small%20cell%20variant%20of%20anaplastic%20large%20cell%20lymphoma%20with%20positive%20immunoreactivity%20for%20CD99.pdf |
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