Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system
Protocatechuic acid, an anticancer agent has been intercalated into Zn/Al-layered double hydroxide at Zn to Al molar ratio of 2 using two different preparation methods; co-precipitation and ion-exchange and labeled as PZAE and PZAC, respectively. The release of the anion, protocatechuate from both o...
| Main Authors: | , , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/17264/1/ABSTRACT%20CAC%202014_2%20medic%2010.pdf |
| _version_ | 1796969221103550464 |
|---|---|
| author | Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain |
| author_facet | Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain |
| author_sort | Barahuie, Farahnaz |
| collection | UPM |
| description | Protocatechuic acid, an anticancer agent has been intercalated into Zn/Al-layered double hydroxide at Zn to Al molar ratio of 2 using two different preparation methods; co-precipitation and ion-exchange and labeled as PZAE and PZAC, respectively. The release of the anion, protocatechuate from both of the nanocomposites occurred in a controlled manner governed by pseudo-second order kinetics. The basal spacing of resulting nanocomposites PZAE and PZAC was 10.2 and 11.0 Å, respectively, indicating successful intercalation of protocatechuate anions into the interlayer galleries of Zn/Al-LDH in monolayer arrangement with an angle of 24 and 33° from z axis for PZAE and PZAC, respectively. The formation of the nanocomposites was confirmed by Fourier transform infrared study and surface area analysis showed that the nanocomposites are of mesoporous-type material. The thermal stability of the intercalated protocatechuic acid significantly enhanced compared to its counterpart, free protocatechuic acid. The drug loading in the nanocomposites was estimated to be about 32.6% in PZAE and 29.2% in PZAC. Both PZAE and PZAC nanocomposites inhibit the growth of human cervical (HeLa), liver (HepG2) and colorectal (HT29) cancer cell lines and show no toxic effect towards normal fibroblast 3T3 cell after 72 hours of treatment. |
| first_indexed | 2024-03-06T07:39:54Z |
| format | Conference or Workshop Item |
| id | upm.eprints-17264 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:39:54Z |
| publishDate | 2014 |
| publisher | UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience |
| record_format | dspace |
| spelling | upm.eprints-172642016-04-26T03:53:03Z http://psasir.upm.edu.my/id/eprint/17264/ Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain Protocatechuic acid, an anticancer agent has been intercalated into Zn/Al-layered double hydroxide at Zn to Al molar ratio of 2 using two different preparation methods; co-precipitation and ion-exchange and labeled as PZAE and PZAC, respectively. The release of the anion, protocatechuate from both of the nanocomposites occurred in a controlled manner governed by pseudo-second order kinetics. The basal spacing of resulting nanocomposites PZAE and PZAC was 10.2 and 11.0 Å, respectively, indicating successful intercalation of protocatechuate anions into the interlayer galleries of Zn/Al-LDH in monolayer arrangement with an angle of 24 and 33° from z axis for PZAE and PZAC, respectively. The formation of the nanocomposites was confirmed by Fourier transform infrared study and surface area analysis showed that the nanocomposites are of mesoporous-type material. The thermal stability of the intercalated protocatechuic acid significantly enhanced compared to its counterpart, free protocatechuic acid. The drug loading in the nanocomposites was estimated to be about 32.6% in PZAE and 29.2% in PZAC. Both PZAE and PZAC nanocomposites inhibit the growth of human cervical (HeLa), liver (HepG2) and colorectal (HT29) cancer cell lines and show no toxic effect towards normal fibroblast 3T3 cell after 72 hours of treatment. UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17264/1/ABSTRACT%20CAC%202014_2%20medic%2010.pdf Barahuie, Farahnaz and Hussein, Mohd Zobir and Abd Gani, Shafinaz and Fakurazi, Sharida and Zainal, Zulkarnain (2014) Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system. In: Scientific Cancer Research Poster Competition in conjunction with Cancer Awareness Carnival 2014, 10 May 2014, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. . |
| spellingShingle | Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system |
| title | Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system |
| title_full | Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system |
| title_fullStr | Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system |
| title_full_unstemmed | Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system |
| title_short | Protocatechuic acid-zinc/aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system |
| title_sort | protocatechuic acid zinc aluminium layered double hydroxide nanocomposite as an anticancer nanodelivery system |
| url | http://psasir.upm.edu.my/id/eprint/17264/1/ABSTRACT%20CAC%202014_2%20medic%2010.pdf |
| work_keys_str_mv | AT barahuiefarahnaz protocatechuicacidzincaluminiumlayereddoublehydroxidenanocompositeasananticancernanodeliverysystem AT husseinmohdzobir protocatechuicacidzincaluminiumlayereddoublehydroxidenanocompositeasananticancernanodeliverysystem AT abdganishafinaz protocatechuicacidzincaluminiumlayereddoublehydroxidenanocompositeasananticancernanodeliverysystem AT fakurazisharida protocatechuicacidzincaluminiumlayereddoublehydroxidenanocompositeasananticancernanodeliverysystem AT zainalzulkarnain protocatechuicacidzincaluminiumlayereddoublehydroxidenanocompositeasananticancernanodeliverysystem |