Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases
The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for the treatment of numerous degenerative disorders including the eye. In retinal degenerative diseases, MSCs exhibit the potential to regenerate into retinal neurons and retinal pigmented epithelial cells in both i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/17285/1/17285.pdf |
| _version_ | 1825945980601630720 |
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| author | Ding, Shirley Suet Lee Subbiah, Suresh Kumar Mok, Pooi Ling |
| author_facet | Ding, Shirley Suet Lee Subbiah, Suresh Kumar Mok, Pooi Ling |
| author_sort | Ding, Shirley Suet Lee |
| collection | UPM |
| description | The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for the treatment of numerous degenerative disorders including the eye. In retinal degenerative diseases, MSCs exhibit the potential to regenerate into retinal neurons and retinal pigmented epithelial cells in both in vitro and in vivo studies. Delivery of MSCs was found to improve retinal morphology and function and delay retinal degeneration. In this review, we revisit the therapeutic role of MSCs in the diseased eye. Furthermore, we reveal the possible cellular mechanisms and identify the associated signaling pathways of MSCs in reversing the pathological conditions of various ocular disorders such as age-related macular degeneration (AMD), retinitis pigmentosa, diabetic retinopathy, and glaucoma. Current stem cell treatment can be dispensed as an independent cell treatment format or with the combination of other approaches. Hence, the improvement of the treatment strategy is largely subjected by our understanding of MSCs mechanism of action. |
| first_indexed | 2024-03-06T07:39:58Z |
| format | Article |
| id | upm.eprints-17285 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:39:58Z |
| publishDate | 2017 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | upm.eprints-172852018-09-24T06:46:57Z http://psasir.upm.edu.my/id/eprint/17285/ Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases Ding, Shirley Suet Lee Subbiah, Suresh Kumar Mok, Pooi Ling The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for the treatment of numerous degenerative disorders including the eye. In retinal degenerative diseases, MSCs exhibit the potential to regenerate into retinal neurons and retinal pigmented epithelial cells in both in vitro and in vivo studies. Delivery of MSCs was found to improve retinal morphology and function and delay retinal degeneration. In this review, we revisit the therapeutic role of MSCs in the diseased eye. Furthermore, we reveal the possible cellular mechanisms and identify the associated signaling pathways of MSCs in reversing the pathological conditions of various ocular disorders such as age-related macular degeneration (AMD), retinitis pigmentosa, diabetic retinopathy, and glaucoma. Current stem cell treatment can be dispensed as an independent cell treatment format or with the combination of other approaches. Hence, the improvement of the treatment strategy is largely subjected by our understanding of MSCs mechanism of action. MDPI AG 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/17285/1/17285.pdf Ding, Shirley Suet Lee and Subbiah, Suresh Kumar and Mok, Pooi Ling (2017) Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases. International Journal of Molecular Sciences, 18 (8). art. no. 1406. pp. 1-19. ISSN 1422-0067 http://www.mdpi.com/1422-0067/18/8/1406 10.3390/ijms18081406 |
| spellingShingle | Ding, Shirley Suet Lee Subbiah, Suresh Kumar Mok, Pooi Ling Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases |
| title | Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases |
| title_full | Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases |
| title_fullStr | Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases |
| title_full_unstemmed | Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases |
| title_short | Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases |
| title_sort | cellular reparative mechanisms of mesenchymal stem cells for retinal diseases |
| url | http://psasir.upm.edu.my/id/eprint/17285/1/17285.pdf |
| work_keys_str_mv | AT dingshirleysuetlee cellularreparativemechanismsofmesenchymalstemcellsforretinaldiseases AT subbiahsureshkumar cellularreparativemechanismsofmesenchymalstemcellsforretinaldiseases AT mokpooiling cellularreparativemechanismsofmesenchymalstemcellsforretinaldiseases |