Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application
In the present study, three-dimensional brushite crystals were prepared through palm olein-in-water high internal phase emulsion processing route for the first time. X-ray diffraction patterns revealed that the powders possessed brushite crystalline phase with trace amount of hydroxyapatite. Unique...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2009
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/17413/1/Three.pdf |
| _version_ | 1825946005789474816 |
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| author | Hong, Ngee Lim Kassim, Anuar Nay, Ming Huang Poi, Sim Khiewcc Wee, Siong Chiuc |
| author_facet | Hong, Ngee Lim Kassim, Anuar Nay, Ming Huang Poi, Sim Khiewcc Wee, Siong Chiuc |
| author_sort | Hong, Ngee Lim |
| collection | UPM |
| description | In the present study, three-dimensional brushite crystals were prepared through palm olein-in-water high internal phase emulsion processing route for the first time. X-ray diffraction patterns revealed that the powders possessed brushite crystalline phase with trace amount of hydroxyapatite. Unique morphologies of the brushite crystals were obtained as a result of tailoring the precursor concentration, surfactant concentration and oil volume fraction. These factors governed the rate of nucleation and crystal growth, resulting in flower-like morphologies. The petal-like flakes grew radially from the centre which gave rise to porosity of less than 2 μm. A plausible mechanism of crystal growth is discussed and postulated schematically. Sodium ampicillin, a broad spectrum antibiotic, was loaded into the pores of the crystals, which was subsequently released in vitro. The controlled release ability for up to 14 days indicated the potential of using these brushite crystals as drug delivery agents for localized treatments.
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| first_indexed | 2024-03-06T07:40:21Z |
| format | Article |
| id | upm.eprints-17413 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:40:21Z |
| publishDate | 2009 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-174132015-09-15T07:47:49Z http://psasir.upm.edu.my/id/eprint/17413/ Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application Hong, Ngee Lim Kassim, Anuar Nay, Ming Huang Poi, Sim Khiewcc Wee, Siong Chiuc In the present study, three-dimensional brushite crystals were prepared through palm olein-in-water high internal phase emulsion processing route for the first time. X-ray diffraction patterns revealed that the powders possessed brushite crystalline phase with trace amount of hydroxyapatite. Unique morphologies of the brushite crystals were obtained as a result of tailoring the precursor concentration, surfactant concentration and oil volume fraction. These factors governed the rate of nucleation and crystal growth, resulting in flower-like morphologies. The petal-like flakes grew radially from the centre which gave rise to porosity of less than 2 μm. A plausible mechanism of crystal growth is discussed and postulated schematically. Sodium ampicillin, a broad spectrum antibiotic, was loaded into the pores of the crystals, which was subsequently released in vitro. The controlled release ability for up to 14 days indicated the potential of using these brushite crystals as drug delivery agents for localized treatments. Elsevier 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17413/1/Three.pdf Hong, Ngee Lim and Kassim, Anuar and Nay, Ming Huang and Poi, Sim Khiewcc and Wee, Siong Chiuc (2009) Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 345 (1-3). pp. 211-218. ISSN 0927-7757 Calcium phosphate Drug delivery systems 10.1016/j.colsurfa.2009.05.008 English |
| spellingShingle | Calcium phosphate Drug delivery systems Hong, Ngee Lim Kassim, Anuar Nay, Ming Huang Poi, Sim Khiewcc Wee, Siong Chiuc Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application |
| title | Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application |
| title_full | Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application |
| title_fullStr | Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application |
| title_full_unstemmed | Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application |
| title_short | Three-dimensional flower-like brushite crystals prepared from high internal phase emulsion for drug delivery application |
| title_sort | three dimensional flower like brushite crystals prepared from high internal phase emulsion for drug delivery application |
| topic | Calcium phosphate Drug delivery systems |
| url | http://psasir.upm.edu.my/id/eprint/17413/1/Three.pdf |
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