Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix
The differentiation between cervical intraepithelial neoplasia 3 (CIN 3) and early squamous cell carcinoma (SCC) of the cervix may be difficult in certain situations. Identification of invasion beyond the basement membrane is the gold standard for the diagnosis of the latter. The objective of this s...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asian Pacific Organization for Cancer Prevention
2008
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/17558/1/Utility%20of%20Ki-67%20and%20p53%20in%20distinguishing%20cervical%20intraepithelial%20neoplasia%203%20from%20squamous%20cell%20carcinoma%20of%20the%20cervix.pdf |
| _version_ | 1825946034016092160 |
|---|---|
| author | Tan, Geok Chin Syed Husain, Sharifah Noor Akmal Mohd Sidik, Shiran Shuib, Salwati Mohd Dali, Ahmad Zailani Hatta Ng, Paul Hock Oon |
| author_facet | Tan, Geok Chin Syed Husain, Sharifah Noor Akmal Mohd Sidik, Shiran Shuib, Salwati Mohd Dali, Ahmad Zailani Hatta Ng, Paul Hock Oon |
| author_sort | Tan, Geok Chin |
| collection | UPM |
| description | The differentiation between cervical intraepithelial neoplasia 3 (CIN 3) and early squamous cell carcinoma (SCC) of the cervix may be difficult in certain situations. Identification of invasion beyond the basement membrane is the gold standard for the diagnosis of the latter. The objective of this study was to determine whether the use of Ki-67 and p53 could help in solving the above dilemma. This was a retrospective study on 61 cases of cervical neoplasms comprising of 25 cases of CIN 3 and 36 SCC. All cases were evaluated by immunohistochemistry using Ki-67 and p53 monoclonal antibodies. Results showed that the differences of Ki-67 and p53 expression between CIN 3 and SCC were statistically significant. In conclusion, Ki-67 and p53 may serve as helpful adjuncts to routinely-stained histological sections in differentiating between CIN 3 and SCC. |
| first_indexed | 2024-03-06T07:40:47Z |
| format | Article |
| id | upm.eprints-17558 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:40:47Z |
| publishDate | 2008 |
| publisher | Asian Pacific Organization for Cancer Prevention |
| record_format | dspace |
| spelling | upm.eprints-175582019-10-23T01:13:20Z http://psasir.upm.edu.my/id/eprint/17558/ Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix Tan, Geok Chin Syed Husain, Sharifah Noor Akmal Mohd Sidik, Shiran Shuib, Salwati Mohd Dali, Ahmad Zailani Hatta Ng, Paul Hock Oon The differentiation between cervical intraepithelial neoplasia 3 (CIN 3) and early squamous cell carcinoma (SCC) of the cervix may be difficult in certain situations. Identification of invasion beyond the basement membrane is the gold standard for the diagnosis of the latter. The objective of this study was to determine whether the use of Ki-67 and p53 could help in solving the above dilemma. This was a retrospective study on 61 cases of cervical neoplasms comprising of 25 cases of CIN 3 and 36 SCC. All cases were evaluated by immunohistochemistry using Ki-67 and p53 monoclonal antibodies. Results showed that the differences of Ki-67 and p53 expression between CIN 3 and SCC were statistically significant. In conclusion, Ki-67 and p53 may serve as helpful adjuncts to routinely-stained histological sections in differentiating between CIN 3 and SCC. Asian Pacific Organization for Cancer Prevention 2008 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/17558/1/Utility%20of%20Ki-67%20and%20p53%20in%20distinguishing%20cervical%20intraepithelial%20neoplasia%203%20from%20squamous%20cell%20carcinoma%20of%20the%20cervix.pdf Tan, Geok Chin and Syed Husain, Sharifah Noor Akmal and Mohd Sidik, Shiran and Shuib, Salwati and Mohd Dali, Ahmad Zailani Hatta and Ng, Paul Hock Oon (2008) Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix. Asian Pacific Journal of Cancer Prevention, 9 (4). pp. 781-784. ISSN 1513-7368; ESSN: 2476-762X http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:19256776&key=2008.9.4.781 |
| spellingShingle | Tan, Geok Chin Syed Husain, Sharifah Noor Akmal Mohd Sidik, Shiran Shuib, Salwati Mohd Dali, Ahmad Zailani Hatta Ng, Paul Hock Oon Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix |
| title | Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix |
| title_full | Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix |
| title_fullStr | Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix |
| title_full_unstemmed | Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix |
| title_short | Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix |
| title_sort | utility of ki 67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix |
| url | http://psasir.upm.edu.my/id/eprint/17558/1/Utility%20of%20Ki-67%20and%20p53%20in%20distinguishing%20cervical%20intraepithelial%20neoplasia%203%20from%20squamous%20cell%20carcinoma%20of%20the%20cervix.pdf |
| work_keys_str_mv | AT tangeokchin utilityofki67andp53indistinguishingcervicalintraepithelialneoplasia3fromsquamouscellcarcinomaofthecervix AT syedhusainsharifahnoorakmal utilityofki67andp53indistinguishingcervicalintraepithelialneoplasia3fromsquamouscellcarcinomaofthecervix AT mohdsidikshiran utilityofki67andp53indistinguishingcervicalintraepithelialneoplasia3fromsquamouscellcarcinomaofthecervix AT shuibsalwati utilityofki67andp53indistinguishingcervicalintraepithelialneoplasia3fromsquamouscellcarcinomaofthecervix AT mohddaliahmadzailanihatta utilityofki67andp53indistinguishingcervicalintraepithelialneoplasia3fromsquamouscellcarcinomaofthecervix AT ngpaulhockoon utilityofki67andp53indistinguishingcervicalintraepithelialneoplasia3fromsquamouscellcarcinomaofthecervix |