Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one ne...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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American Society of Pharmacognosy & American Chemical Society
2009
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf |
| _version_ | 1796969310911987712 |
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| author | Cheenpracha, Sarot Hui, Zhang Mar, Annie M. N. Foss, Adam P. Sek, Hin Foo Ngit, Shin Lai Jap, Meng Jee Heng, Fong Seow Coy, Choke Ho Leng, Chee Chang |
| author_facet | Cheenpracha, Sarot Hui, Zhang Mar, Annie M. N. Foss, Adam P. Sek, Hin Foo Ngit, Shin Lai Jap, Meng Jee Heng, Fong Seow Coy, Choke Ho Leng, Chee Chang |
| author_sort | Cheenpracha, Sarot |
| collection | UPM |
| description | Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new
imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H
and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 assay. |
| first_indexed | 2024-03-06T07:41:07Z |
| format | Article |
| id | upm.eprints-17669 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:41:07Z |
| publishDate | 2009 |
| publisher | American Society of Pharmacognosy & American Chemical Society |
| record_format | dspace |
| spelling | upm.eprints-176692015-11-03T07:41:07Z http://psasir.upm.edu.my/id/eprint/17669/ Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. Cheenpracha, Sarot Hui, Zhang Mar, Annie M. N. Foss, Adam P. Sek, Hin Foo Ngit, Shin Lai Jap, Meng Jee Heng, Fong Seow Coy, Choke Ho Leng, Chee Chang Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 assay. American Society of Pharmacognosy & American Chemical Society 2009-11-08 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf Cheenpracha, Sarot and Hui, Zhang and Mar, Annie M. N. and Foss, Adam P. and Sek, Hin Foo and Ngit, Shin Lai and Jap, Meng Jee and Heng, Fong Seow and Coy, Choke Ho and Leng, Chee Chang (2009) Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864 & Online ISSN: 1520-6025 http://pubs.acs.org/toc/jnprdf/72/8 Glycogen synthase kinase-3. Streptomyces. 10.1021/np900163f English |
| spellingShingle | Glycogen synthase kinase-3. Streptomyces. Cheenpracha, Sarot Hui, Zhang Mar, Annie M. N. Foss, Adam P. Sek, Hin Foo Ngit, Shin Lai Jap, Meng Jee Heng, Fong Seow Coy, Choke Ho Leng, Chee Chang Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. |
| title | Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. |
| title_full | Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. |
| title_fullStr | Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. |
| title_full_unstemmed | Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. |
| title_short | Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. |
| title_sort | yeast glycogen synthase kinase 3 pathway inhibitors from an organic extract of streptomyces sp |
| topic | Glycogen synthase kinase-3. Streptomyces. |
| url | http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf |
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