Self built of laboratory scale supercritical anti solvent system
Supercritical fluid (SCF) particles formation technique gained a significant attention mainly in the pharmaceutical, cosmetic and paints. However, the scarcity of information on the design and process for this type of laboratory scale equipment is a significant drawback to the technological progress...
| Main Authors: | , , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/18210/1/ID%2018210.docx |
| _version_ | 1825946151439826944 |
|---|---|
| author | Chong, G. H. R., Yunus Choong, Thomas Shean Yaw Abdullah, N. Spotar, S. Y. |
| author_facet | Chong, G. H. R., Yunus Choong, Thomas Shean Yaw Abdullah, N. Spotar, S. Y. |
| author_sort | Chong, G. H. |
| collection | UPM |
| description | Supercritical fluid (SCF) particles formation technique gained a significant attention mainly in the pharmaceutical, cosmetic and paints. However, the scarcity of information on the design and process for this type of laboratory scale equipment is a significant drawback to the technological progress. Therefore, the purpose of this study was to design and build a laboratory supercritical anti solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The operating conditions of the constructed system affected the yield. The optimum operating conditions were then determined as: 110 bars, 35° C, 35 mg/ml of polymer concentration and 1.75 ml/min of feed flow rate. The microparticles and microcapsules were characterized on its morphology (scanning electron microscopy), size distribution (particle size analyzer), thermal properties (thermo gravimetetric analyzer) and crystallographic (X-ray powder diffraction). The in vitro drug released of the microparticles and microcapsules were also investigated. The results revealed a more homogenous microparticle size distribution, a change in the crystalinity and maintained of drug thermal stability after the SAS process. Furthermore, the microcapsules prolong the drug released significantly in the in vitro study. |
| first_indexed | 2024-03-06T07:42:35Z |
| format | Conference or Workshop Item |
| id | upm.eprints-18210 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:42:35Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | upm.eprints-182102015-01-05T08:05:22Z http://psasir.upm.edu.my/id/eprint/18210/ Self built of laboratory scale supercritical anti solvent system Chong, G. H. R., Yunus Choong, Thomas Shean Yaw Abdullah, N. Spotar, S. Y. Supercritical fluid (SCF) particles formation technique gained a significant attention mainly in the pharmaceutical, cosmetic and paints. However, the scarcity of information on the design and process for this type of laboratory scale equipment is a significant drawback to the technological progress. Therefore, the purpose of this study was to design and build a laboratory supercritical anti solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The operating conditions of the constructed system affected the yield. The optimum operating conditions were then determined as: 110 bars, 35° C, 35 mg/ml of polymer concentration and 1.75 ml/min of feed flow rate. The microparticles and microcapsules were characterized on its morphology (scanning electron microscopy), size distribution (particle size analyzer), thermal properties (thermo gravimetetric analyzer) and crystallographic (X-ray powder diffraction). The in vitro drug released of the microparticles and microcapsules were also investigated. The results revealed a more homogenous microparticle size distribution, a change in the crystalinity and maintained of drug thermal stability after the SAS process. Furthermore, the microcapsules prolong the drug released significantly in the in vitro study. 2010 Conference or Workshop Item NonPeerReviewed application/msword en http://psasir.upm.edu.my/id/eprint/18210/1/ID%2018210.docx Chong, G. H. and R., Yunus and Choong, Thomas Shean Yaw and Abdullah, N. and Spotar, S. Y. (2010) Self built of laboratory scale supercritical anti solvent system. In: 9th Conference on Supercritical Fluids and Their Applications, 5-8 Sep. 2010, Sorrento, Italy. . (Unpublished) Supercritical fluids Solvents |
| spellingShingle | Supercritical fluids Solvents Chong, G. H. R., Yunus Choong, Thomas Shean Yaw Abdullah, N. Spotar, S. Y. Self built of laboratory scale supercritical anti solvent system |
| title | Self built of laboratory scale supercritical anti solvent system |
| title_full | Self built of laboratory scale supercritical anti solvent system |
| title_fullStr | Self built of laboratory scale supercritical anti solvent system |
| title_full_unstemmed | Self built of laboratory scale supercritical anti solvent system |
| title_short | Self built of laboratory scale supercritical anti solvent system |
| title_sort | self built of laboratory scale supercritical anti solvent system |
| topic | Supercritical fluids Solvents |
| url | http://psasir.upm.edu.my/id/eprint/18210/1/ID%2018210.docx |
| work_keys_str_mv | AT chonggh selfbuiltoflaboratoryscalesupercriticalantisolventsystem AT ryunus selfbuiltoflaboratoryscalesupercriticalantisolventsystem AT choongthomassheanyaw selfbuiltoflaboratoryscalesupercriticalantisolventsystem AT abdullahn selfbuiltoflaboratoryscalesupercriticalantisolventsystem AT spotarsy selfbuiltoflaboratoryscalesupercriticalantisolventsystem |