Bioactive constituents of melicope bonwickii and m. lunu-ankeda (rutaceae).
The used of natural products from plant source with therapeutic properties is ancient as human civilization. Currently about 25% of modern drugs prescribed worldwide come from plants and 121 such active compounds are being used. Of the 252 drugs considered as basic and essential by World Health Orga...
| Main Authors: | , , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
2005
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/18939/1/ID%2018939.pdf |
| Summary: | The used of natural products from plant source with therapeutic properties is ancient as human civilization. Currently about 25% of modern drugs prescribed worldwide come from plants and 121 such active compounds are being used. Of the 252 drugs considered as basic and essential by World Health Organization (WHO), 11% are exclusively of plants origin and a significant number are synthetic drugs obtained from natural precursors. Deatiled phytochemical study of Melicope bonwickii (F. Muell) T. Hartley revealed the presence of four furoquinoline alkaloids in which one is a rare new chlorine-containing compound, 7(2',-hydroxy-3'-chloroprenyloxy)-4-methoxyfuroquinoline, three known alkaloids 7-(2',3'-epoxyprenyloxy)-4-methoxyfuroquinoline, evellerine and kokusaginine together with a known dipeptide, aurantiamide acetate. From leaves of Melicope lunu-ankeda (Geartn) T. Hartley, two phenylpropanoid derivatives,p-)-geranylcoumaric acid and sesamin, a quinolone alkaloid and a flavanoid were isolated and identified. The ectracts and the isolated compounds were evaluated for their antioxidant, cytotoxity and antimicrobial activities. The new furoquinoline alkaloid and 7-(2',3'-epoxyprenyloxy)-4-methoxyfuroquinoline exhibited significant cytotoxic activity against cervical cancer (Hela) cell line with IC50 values were found to be 6.0 and 11.4 µg/ml, respectively. |
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