Optimized Synthesis of Lipase-Catalyzed 3-O-(3',3'-Dimethylsuccinyl)-Betulinic Acid by Immobilised Novozyme 435
The derivative of betulinic acid, 3-O-(3',3'-dimethylsuccinyl)-betulinic acid (5) was successfully synthesized by the reaction of betulinic acid and 2,2-dimethylsuccinic anhydride, catalyzed by immobilized lipase from Candida antartica (Novozyme 435) in chloroform. The structure of the pro...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/19583/1/FS_2010_33_F.pdf |