Safety and clinical usage of Newcastle disease virus in cancer therapy.
Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. T...
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| Format: | Article |
| Language: | English English |
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Hindawi Publishing Corporation
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/22230/1/Safety%20and%20clinical%20usage%20of%20Newcastle%20disease%20virus%20in%20cancer%20therapy.pdf |
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| author | Lam, Han Yuen Yeap, Swee Keong Rasoli, Mehdi Omar, Abdul Rahman Yusoff, Khatijah Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu |
| author_facet | Lam, Han Yuen Yeap, Swee Keong Rasoli, Mehdi Omar, Abdul Rahman Yusoff, Khatijah Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu |
| author_sort | Lam, Han Yuen |
| collection | UPM |
| description | Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the
potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, specially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV stra
ins applied for cancer immunotherapy is also discussed in this paper. |
| first_indexed | 2024-03-06T07:53:20Z |
| format | Article |
| id | upm.eprints-22230 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:53:20Z |
| publishDate | 2011 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | upm.eprints-222302015-10-05T02:40:12Z http://psasir.upm.edu.my/id/eprint/22230/ Safety and clinical usage of Newcastle disease virus in cancer therapy. Lam, Han Yuen Yeap, Swee Keong Rasoli, Mehdi Omar, Abdul Rahman Yusoff, Khatijah Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, specially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV stra ins applied for cancer immunotherapy is also discussed in this paper. Hindawi Publishing Corporation 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22230/1/Safety%20and%20clinical%20usage%20of%20Newcastle%20disease%20virus%20in%20cancer%20therapy.pdf Lam, Han Yuen and Yeap, Swee Keong and Rasoli, Mehdi and Omar, Abdul Rahman and Yusoff, Khatijah and Abd. Aziz, Suraini and Mohamed Alitheen, Noorjahan Banu (2011) Safety and clinical usage of Newcastle disease virus in cancer therapy. Journal of Biomedicine and Biotechnology, 2011 (718710). pp. 1-13. ISSN 1110-7243; ESSN: 1110-7251 http://www.hindawi.com/journals/bmri/2011/718710/ 10.1155/2011/718710 English |
| spellingShingle | Lam, Han Yuen Yeap, Swee Keong Rasoli, Mehdi Omar, Abdul Rahman Yusoff, Khatijah Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu Safety and clinical usage of Newcastle disease virus in cancer therapy. |
| title | Safety and clinical usage of Newcastle disease virus in cancer therapy. |
| title_full | Safety and clinical usage of Newcastle disease virus in cancer therapy. |
| title_fullStr | Safety and clinical usage of Newcastle disease virus in cancer therapy. |
| title_full_unstemmed | Safety and clinical usage of Newcastle disease virus in cancer therapy. |
| title_short | Safety and clinical usage of Newcastle disease virus in cancer therapy. |
| title_sort | safety and clinical usage of newcastle disease virus in cancer therapy |
| url | http://psasir.upm.edu.my/id/eprint/22230/1/Safety%20and%20clinical%20usage%20of%20Newcastle%20disease%20virus%20in%20cancer%20therapy.pdf |
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