Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration
This paper investigates the membrane purification and fractionation of a mixture containing the homologous series of cyclodextrins CD6 to CD60 obtained by enzymatic conversion of starch. Three commercial polyamide thin film composite NF and UF membranes (HL, GH and GK from GE-Osmonics) were used for...
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| Format: | Article |
| Language: | English |
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Elsevier
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/22963/1/Fractionation%20of%20homologous%20CD6%20to%20CD60%20cyclodextrin%20mixture%20by%20ultrafiltration%20and%20nanofiltration.pdf |
| _version_ | 1796970266222395392 |
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| author | Ellouze, Fatma Ben Amar, Nihel Mokhtar, Mohd Noriznan Zimmermann, Wolfgang Deratani, Andre |
| author_facet | Ellouze, Fatma Ben Amar, Nihel Mokhtar, Mohd Noriznan Zimmermann, Wolfgang Deratani, Andre |
| author_sort | Ellouze, Fatma |
| collection | UPM |
| description | This paper investigates the membrane purification and fractionation of a mixture containing the homologous series of cyclodextrins CD6 to CD60 obtained by enzymatic conversion of starch. Three commercial polyamide thin film composite NF and UF membranes (HL, GH and GK from GE-Osmonics) were used for this purpose. In a first step, a binary mixture composed of glucose and heptacyclomaltose (β-cyclodextrin, CD7) was filtered to examine the separation performance of the studied membranes. A mathematical model based on mass balance was proposed for the simulation of the discontinuous diafiltration process assuming that the membrane separation performance is based on a sieving mechanism. A three stage diafiltration cascade (in retentate configuration) was then selected to fractionate the CD6–CD60 crude mixture. The experimental composition of the obtained permeate and retentate solutions in the targeted fractions (glucose, CD6–CD8, CD9–CD21, CD22–CD60) fit well with the predicted data indicating that membrane process enables purification and fractionation of the homologous series of large ring CDs. Some discrepancies were however observed implying that other mechanisms such as coupled transport also took place. The most striking effect was the presence of glucose in the GK retentate possibly as a result of the formation of inclusion complexes with the large ring CDs. |
| first_indexed | 2024-03-06T07:55:30Z |
| format | Article |
| id | upm.eprints-22963 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:55:30Z |
| publishDate | 2011 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-229632015-12-09T08:21:07Z http://psasir.upm.edu.my/id/eprint/22963/ Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration Ellouze, Fatma Ben Amar, Nihel Mokhtar, Mohd Noriznan Zimmermann, Wolfgang Deratani, Andre This paper investigates the membrane purification and fractionation of a mixture containing the homologous series of cyclodextrins CD6 to CD60 obtained by enzymatic conversion of starch. Three commercial polyamide thin film composite NF and UF membranes (HL, GH and GK from GE-Osmonics) were used for this purpose. In a first step, a binary mixture composed of glucose and heptacyclomaltose (β-cyclodextrin, CD7) was filtered to examine the separation performance of the studied membranes. A mathematical model based on mass balance was proposed for the simulation of the discontinuous diafiltration process assuming that the membrane separation performance is based on a sieving mechanism. A three stage diafiltration cascade (in retentate configuration) was then selected to fractionate the CD6–CD60 crude mixture. The experimental composition of the obtained permeate and retentate solutions in the targeted fractions (glucose, CD6–CD8, CD9–CD21, CD22–CD60) fit well with the predicted data indicating that membrane process enables purification and fractionation of the homologous series of large ring CDs. Some discrepancies were however observed implying that other mechanisms such as coupled transport also took place. The most striking effect was the presence of glucose in the GK retentate possibly as a result of the formation of inclusion complexes with the large ring CDs. Elsevier 2011-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22963/1/Fractionation%20of%20homologous%20CD6%20to%20CD60%20cyclodextrin%20mixture%20by%20ultrafiltration%20and%20nanofiltration.pdf Ellouze, Fatma and Ben Amar, Nihel and Mokhtar, Mohd Noriznan and Zimmermann, Wolfgang and Deratani, Andre (2011) Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration. Journal of Membrane Science, 374 (1-2). pp. 129-137. ISSN 0376-7388; ESSN: 1873-3123 http://www.sciencedirect.com/science/article/pii/S0376738811002018 10.1016/j.memsci.2011.03.025 |
| spellingShingle | Ellouze, Fatma Ben Amar, Nihel Mokhtar, Mohd Noriznan Zimmermann, Wolfgang Deratani, Andre Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration |
| title | Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration |
| title_full | Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration |
| title_fullStr | Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration |
| title_full_unstemmed | Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration |
| title_short | Fractionation of homologous CD6 to CD60 cyclodextrin mixture by ultrafiltration and nanofiltration |
| title_sort | fractionation of homologous cd6 to cd60 cyclodextrin mixture by ultrafiltration and nanofiltration |
| url | http://psasir.upm.edu.my/id/eprint/22963/1/Fractionation%20of%20homologous%20CD6%20to%20CD60%20cyclodextrin%20mixture%20by%20ultrafiltration%20and%20nanofiltration.pdf |
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