Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats.
This study was conducted to investigate the effects of modifying the n-6:n-3 Fatty Acid Ratio (FAR) of diets using fish oil, soybean oil and butter on growth performance and the fatty acid profile of rat fed with commercial concentrate diet. Fifty individually housed Sprague-Dawley rats (average of...
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| Format: | Article |
| Language: | English English |
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Medwell Online
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/23627/1/Effects%20of%20long%20term%20polyunsaturated%20fatty%20acids%20supplementation%20on%20membrane%20lipid%20composition%20and%20growth%20characteristics%20in%20rats.pdf |
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| author | Tan, A.L. Ebrahimi, M. Hajjar, T. Vidyadaran, Sharmili Sazili, Awis Qurni Rajion, Mohamed Ali Goh , Yong Meng |
| author_facet | Tan, A.L. Ebrahimi, M. Hajjar, T. Vidyadaran, Sharmili Sazili, Awis Qurni Rajion, Mohamed Ali Goh , Yong Meng |
| author_sort | Tan, A.L. |
| collection | UPM |
| description | This study was conducted to investigate the effects of modifying the n-6:n-3 Fatty Acid Ratio (FAR) of diets using fish oil, soybean oil and butter on growth performance and the fatty acid profile of rat fed with commercial concentrate diet. Fifty individually housed Sprague-Dawley rats (average of 130±2 g of body weight) were fed concentrates at 5% of body weight daily. The treatments consisted of dietary n-6:n-3 FAR of 1.94:1, 5.67:1, 51.82:1 and 61.69:1. After feeding for 20 weeks in individual cages, rats were sacrificed 15 h after feeding and samples of blood were collected. Increasing dietary saturated fatty acid increased the body weight significantly in compared to other treatment groups. Concentrations of n-6:n-3 FAR in plasma increased linearly (p<0.05) with increasing dietary n-6:n-3 FAR. Concentrations of CI 8:3 n-3 decreased (p<0.001) in the diet with high level of soybean oil whereas that of CI 8:2n-6 did not change in all treatment groups (p>0.05) in rat plasma with different n-6:n-3 FAR. Proportions of oleic acid in plasma were unchanged by diet. The proportion of Arachidonic Acid (AA) decreased (p<0.05) in plasma of rat that fed with low level of n-6:n-3 FAR in compare to the diet with higher level. Proportions of all measured long chain n-3 fatty acids were greater in plasma when diets contained more C22:5 n-3 and 22:6 n-3 from fish oil. By decreasing the dietary n-6:n-3 FAR, the proportions of long chain n-3 fatty acids in plasma increased dramatically; specifically, 22:6 n-3 and 22:5 n-3. |
| first_indexed | 2024-03-06T07:57:26Z |
| format | Article |
| id | upm.eprints-23627 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:57:26Z |
| publishDate | 2011 |
| publisher | Medwell Online |
| record_format | dspace |
| spelling | upm.eprints-236272016-01-12T03:50:20Z http://psasir.upm.edu.my/id/eprint/23627/ Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. Tan, A.L. Ebrahimi, M. Hajjar, T. Vidyadaran, Sharmili Sazili, Awis Qurni Rajion, Mohamed Ali Goh , Yong Meng This study was conducted to investigate the effects of modifying the n-6:n-3 Fatty Acid Ratio (FAR) of diets using fish oil, soybean oil and butter on growth performance and the fatty acid profile of rat fed with commercial concentrate diet. Fifty individually housed Sprague-Dawley rats (average of 130±2 g of body weight) were fed concentrates at 5% of body weight daily. The treatments consisted of dietary n-6:n-3 FAR of 1.94:1, 5.67:1, 51.82:1 and 61.69:1. After feeding for 20 weeks in individual cages, rats were sacrificed 15 h after feeding and samples of blood were collected. Increasing dietary saturated fatty acid increased the body weight significantly in compared to other treatment groups. Concentrations of n-6:n-3 FAR in plasma increased linearly (p<0.05) with increasing dietary n-6:n-3 FAR. Concentrations of CI 8:3 n-3 decreased (p<0.001) in the diet with high level of soybean oil whereas that of CI 8:2n-6 did not change in all treatment groups (p>0.05) in rat plasma with different n-6:n-3 FAR. Proportions of oleic acid in plasma were unchanged by diet. The proportion of Arachidonic Acid (AA) decreased (p<0.05) in plasma of rat that fed with low level of n-6:n-3 FAR in compare to the diet with higher level. Proportions of all measured long chain n-3 fatty acids were greater in plasma when diets contained more C22:5 n-3 and 22:6 n-3 from fish oil. By decreasing the dietary n-6:n-3 FAR, the proportions of long chain n-3 fatty acids in plasma increased dramatically; specifically, 22:6 n-3 and 22:5 n-3. Medwell Online 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/23627/1/Effects%20of%20long%20term%20polyunsaturated%20fatty%20acids%20supplementation%20on%20membrane%20lipid%20composition%20and%20growth%20characteristics%20in%20rats.pdf Tan, A.L. and Ebrahimi, M. and Hajjar, T. and Vidyadaran, Sharmili and Sazili, Awis Qurni and Rajion, Mohamed Ali and Goh , Yong Meng (2011) Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. Journal of Animal and Veterinary Advances, 10 (19). pp. 2575-2581. ISSN 1680-5593; ESSN:1993-601X http://www.medwelljournals.com/ 10.3923/javaa.2011.2575.2581 English |
| spellingShingle | Tan, A.L. Ebrahimi, M. Hajjar, T. Vidyadaran, Sharmili Sazili, Awis Qurni Rajion, Mohamed Ali Goh , Yong Meng Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. |
| title | Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. |
| title_full | Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. |
| title_fullStr | Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. |
| title_full_unstemmed | Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. |
| title_short | Effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats. |
| title_sort | effects of long term polyunsaturated fatty acids supplementation on membrane lipid composition and growth characteristics in rats |
| url | http://psasir.upm.edu.my/id/eprint/23627/1/Effects%20of%20long%20term%20polyunsaturated%20fatty%20acids%20supplementation%20on%20membrane%20lipid%20composition%20and%20growth%20characteristics%20in%20rats.pdf |
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