Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat
The main objective of this investigation was to explore the improvement effect of oral administration of zerumbone on the density of protein gene product; calcitonin gene related peptide and neuropeptide Y immunoreactive nerve fibers against monosodium iodoacetate induced osteoarthritis changes in r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Academic Journals
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/23828/1/23828.pdf |
| _version_ | 1796970438070370304 |
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| author | Al-Saffar, Fayak Jabbar Taqi Ganabadi, Shanthi Fakurazi, Sharida Yaakub, Halimatun |
| author_facet | Al-Saffar, Fayak Jabbar Taqi Ganabadi, Shanthi Fakurazi, Sharida Yaakub, Halimatun |
| author_sort | Al-Saffar, Fayak Jabbar Taqi |
| collection | UPM |
| description | The main objective of this investigation was to explore the improvement effect of oral administration of zerumbone on the density of protein gene product; calcitonin gene related peptide and neuropeptide Y immunoreactive nerve fibers against monosodium iodoacetate induced osteoarthritis changes in rat's knee synovial membrane. Prostaglandin (PG) E2 and F2α were determined to assess their role during osteoarthritis events and post zerumbone application. Forty rats were divided equally into four groups. Rats in the first and second groups were treated with two different concentrations of zerumbone. Rats in the third group received celecoxib (Celebrex®) and served as positive control; whereas those of the fourth group were given corn oil and served as the negative control. The results revealed lower pathology score beside an improvement of the immunoreactive nerve fibers densities in zerumbone treated groups compared with the negative control. Different prostaglandin levels were detected within the different treated groups. The data showed that, zerumbone had dose dependent plausible improvement effect against the depleted immunoreactive nerve fibers which occurred after monosodium iodoacetate injection. The prostaglandin E2 but not PGF2α showed distinct role during the osteoarthritis events and the post oral treatment with zerumbone. |
| first_indexed | 2024-03-06T07:58:02Z |
| format | Article |
| id | upm.eprints-23828 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:58:02Z |
| publishDate | 2011 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | upm.eprints-238282017-11-13T04:19:47Z http://psasir.upm.edu.my/id/eprint/23828/ Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat Al-Saffar, Fayak Jabbar Taqi Ganabadi, Shanthi Fakurazi, Sharida Yaakub, Halimatun The main objective of this investigation was to explore the improvement effect of oral administration of zerumbone on the density of protein gene product; calcitonin gene related peptide and neuropeptide Y immunoreactive nerve fibers against monosodium iodoacetate induced osteoarthritis changes in rat's knee synovial membrane. Prostaglandin (PG) E2 and F2α were determined to assess their role during osteoarthritis events and post zerumbone application. Forty rats were divided equally into four groups. Rats in the first and second groups were treated with two different concentrations of zerumbone. Rats in the third group received celecoxib (Celebrex®) and served as positive control; whereas those of the fourth group were given corn oil and served as the negative control. The results revealed lower pathology score beside an improvement of the immunoreactive nerve fibers densities in zerumbone treated groups compared with the negative control. Different prostaglandin levels were detected within the different treated groups. The data showed that, zerumbone had dose dependent plausible improvement effect against the depleted immunoreactive nerve fibers which occurred after monosodium iodoacetate injection. The prostaglandin E2 but not PGF2α showed distinct role during the osteoarthritis events and the post oral treatment with zerumbone. Academic Journals 2011-05-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/23828/1/23828.pdf Al-Saffar, Fayak Jabbar Taqi and Ganabadi, Shanthi and Fakurazi, Sharida and Yaakub, Halimatun (2011) Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat. African Journal of Biotechnology, 10 (18). art. no. 643B16B24601. pp. 3646-3653. ISSN 1684–5315 http://www.academicjournals.org/journal/AJB/article-abstract/643B16B24601 10.5897/AJB10.2371 |
| spellingShingle | Al-Saffar, Fayak Jabbar Taqi Ganabadi, Shanthi Fakurazi, Sharida Yaakub, Halimatun Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat |
| title | Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat |
| title_full | Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat |
| title_fullStr | Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat |
| title_full_unstemmed | Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat |
| title_short | Zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat |
| title_sort | zerumbone improved immunoreactivity of neuropeptides in monosodium iodoacetate induced knee osteoarthritis in rat |
| url | http://psasir.upm.edu.my/id/eprint/23828/1/23828.pdf |
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