Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats.
Ficus religiosa is being used in Ayurvedic and Malay traditional medicine for the treatment of various diseases including gastric ulcer. Considering the above claims, the present work was undertaken to validate the anti-ulcer potential of the ethanol extract of stem bark of F. religiosa agains...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Academic Journals
2011
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/24413/1/Anti-ulcer.pdf |
| _version_ | 1796970555613642752 |
|---|---|
| author | Ali Khan, Mohammed Safwan Hussain, Syed Ahmed Mat Jais, Abdul Manan Zakaria, Zainul Amiruddin Mohib Khan, |
| author_facet | Ali Khan, Mohammed Safwan Hussain, Syed Ahmed Mat Jais, Abdul Manan Zakaria, Zainul Amiruddin Mohib Khan, |
| author_sort | Ali Khan, Mohammed Safwan |
| collection | UPM |
| description | Ficus religiosa is being used in Ayurvedic and Malay traditional medicine for the treatment of various
diseases including gastric ulcer.
Considering the above claims, the present work was undertaken to
validate the anti-ulcer potential of the ethanol extract of stem bark of F. religiosa against in vivo
indomethacin- and cold restrained stress-induced gastric ulcer, and pylorus ligation assays. The
extract (100, 200 and 400 mg/kg) significantly (P<0.05) reduced the ulcer index in all assays used. The
extract also significantly (P<0.05) and increased the pH of gastric acid while at the same time reduced
the volume of gastric juice and, free and total acidities. In conclusion, the present study provide
preliminary data on the antiulcer potential of F. religiosa stem bark and support the traditional uses of
the plant for the treatment of gastric ulcer. |
| first_indexed | 2024-03-06T07:59:47Z |
| format | Article |
| id | upm.eprints-24413 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:59:47Z |
| publishDate | 2011 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | upm.eprints-244132015-10-02T03:01:07Z http://psasir.upm.edu.my/id/eprint/24413/ Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. Ali Khan, Mohammed Safwan Hussain, Syed Ahmed Mat Jais, Abdul Manan Zakaria, Zainul Amiruddin Mohib Khan, Ficus religiosa is being used in Ayurvedic and Malay traditional medicine for the treatment of various diseases including gastric ulcer. Considering the above claims, the present work was undertaken to validate the anti-ulcer potential of the ethanol extract of stem bark of F. religiosa against in vivo indomethacin- and cold restrained stress-induced gastric ulcer, and pylorus ligation assays. The extract (100, 200 and 400 mg/kg) significantly (P<0.05) reduced the ulcer index in all assays used. The extract also significantly (P<0.05) and increased the pH of gastric acid while at the same time reduced the volume of gastric juice and, free and total acidities. In conclusion, the present study provide preliminary data on the antiulcer potential of F. religiosa stem bark and support the traditional uses of the plant for the treatment of gastric ulcer. Academic Journals 2011-02-04 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24413/1/Anti-ulcer.pdf Ali Khan, Mohammed Safwan and Hussain, Syed Ahmed and Mat Jais, Abdul Manan and Zakaria, Zainul Amiruddin and Mohib Khan, (2011) Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. Journal of Medicinal Plants Research, 5 (3). pp. 354-359. ISSN 1996-0875 http://www.academicjournals.org/journal/JMPR English |
| spellingShingle | Ali Khan, Mohammed Safwan Hussain, Syed Ahmed Mat Jais, Abdul Manan Zakaria, Zainul Amiruddin Mohib Khan, Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. |
| title | Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. |
| title_full | Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. |
| title_fullStr | Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. |
| title_full_unstemmed | Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. |
| title_short | Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. |
| title_sort | anti ulcer activity of ficus religiosa stem bark ethanolic extract in rats |
| url | http://psasir.upm.edu.my/id/eprint/24413/1/Anti-ulcer.pdf |
| work_keys_str_mv | AT alikhanmohammedsafwan antiulceractivityofficusreligiosastembarkethanolicextractinrats AT hussainsyedahmed antiulceractivityofficusreligiosastembarkethanolicextractinrats AT matjaisabdulmanan antiulceractivityofficusreligiosastembarkethanolicextractinrats AT zakariazainulamiruddin antiulceractivityofficusreligiosastembarkethanolicextractinrats AT mohibkhan antiulceractivityofficusreligiosastembarkethanolicextractinrats |