Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients.
Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with end-stage renal disease (ESRD) subjects in many different populations, although with conflicting results. We determined the 70 bp of VNTR polymorphism at intron 3 of the IL-4 gene in Malay...
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| Format: | Article |
| Language: | English English |
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Fundacao de Pesquisas Cientificas de Ribeirao Preto
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24418/1/Association%20of%20variable%20number%20of%20tandem%20repeats%20polymorphism%20in%20the%20IL.pdf |
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| author | Vasudevan, R. M. N., Norhasniza Ismail, Patimah |
| author_facet | Vasudevan, R. M. N., Norhasniza Ismail, Patimah |
| author_sort | Vasudevan, R. |
| collection | UPM |
| description | Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with end-stage renal disease (ESRD) subjects in many different populations, although with conflicting results. We determined the 70 bp of VNTR polymorphism at intron 3 of the IL-4 gene in Malaysian ESRD subjects. Buccal cells were collected from 160 case and 160 control subjects; genomic DNA was amplified using PCR, followed by agarose gel electrophoresis. There were significant differences in genotypes and alleles of the IL-4 gene. We conclude that VNTR polymorphism of the IL-4 gene is a risk factor for the development of ESRD among Malaysians. |
| first_indexed | 2024-03-06T07:59:48Z |
| format | Article |
| id | upm.eprints-24418 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:59:48Z |
| publishDate | 2011 |
| publisher | Fundacao de Pesquisas Cientificas de Ribeirao Preto |
| record_format | dspace |
| spelling | upm.eprints-244182015-10-07T04:34:32Z http://psasir.upm.edu.my/id/eprint/24418/ Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. Vasudevan, R. M. N., Norhasniza Ismail, Patimah Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with end-stage renal disease (ESRD) subjects in many different populations, although with conflicting results. We determined the 70 bp of VNTR polymorphism at intron 3 of the IL-4 gene in Malaysian ESRD subjects. Buccal cells were collected from 160 case and 160 control subjects; genomic DNA was amplified using PCR, followed by agarose gel electrophoresis. There were significant differences in genotypes and alleles of the IL-4 gene. We conclude that VNTR polymorphism of the IL-4 gene is a risk factor for the development of ESRD among Malaysians. Fundacao de Pesquisas Cientificas de Ribeirao Preto 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24418/1/Association%20of%20variable%20number%20of%20tandem%20repeats%20polymorphism%20in%20the%20IL.pdf Vasudevan, R. and M. N., Norhasniza and Ismail, Patimah (2011) Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. Genetics and Molecular Research, 10 (2). pp. 943-947. ISSN 1676-5680 http://www.geneticsmr.com/ 10.4238/vol10-2gmr1066 English |
| spellingShingle | Vasudevan, R. M. N., Norhasniza Ismail, Patimah Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. |
| title | Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. |
| title_full | Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. |
| title_fullStr | Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. |
| title_full_unstemmed | Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. |
| title_short | Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. |
| title_sort | association of variable number of tandem repeats polymorphism in the il 4 gene with end stage renal disease in malaysian patients |
| url | http://psasir.upm.edu.my/id/eprint/24418/1/Association%20of%20variable%20number%20of%20tandem%20repeats%20polymorphism%20in%20the%20IL.pdf |
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