Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects..
Purpose: Prostate cancer differs markedly in incidence across ethnic groups. Since this disease is influenced by complex genetics, it is many genetic factors may affect the level of susceptibility to development of the disease. In this study, four Y-linked short tandem repeats (STRs), DYS388, DY...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Asian Pacific Organization for Cancer Prevention
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24419/1/Linkage%20between%20prostate%20cancer%20occurrence%20and%20Y.pdf |
| _version_ | 1825925568141459456 |
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| author | Nargesi, Mirsaed Miri Ismail, Patimah Abdul Razack, Azad Hassan Pasalar, Parvin Nazemi, Ali Oshkoor, Sima Attaollahi Amini, Peyman |
| author_facet | Nargesi, Mirsaed Miri Ismail, Patimah Abdul Razack, Azad Hassan Pasalar, Parvin Nazemi, Ali Oshkoor, Sima Attaollahi Amini, Peyman |
| author_sort | Nargesi, Mirsaed Miri |
| collection | UPM |
| description | Purpose: Prostate cancer differs markedly in incidence across ethnic groups. Since this disease is influenced by
complex genetics, it is many genetic factors may affect the level of susceptibility to development of the disease. In
this study, four Y-linked short tandem repeats (STRs), DYS388, DYS435, DYS437, and DYS439, were genotyped
to compare Malaysian prostate cancer patients and normal control males. Materials and methods: A total of
175 subjects comprising 84 patients and 91 healthy individuals were recruited. Multiplex PCR was optimized
to co-amplify DYS388, DYS435, DYS437, and DYS439 loci. All samples were genotyped for alleles of four DYS
loci using a Genetic Analysis System. Results: Of all DYS loci, allele 10 (A) of DYS388 had a significantly lower
incidence of disease in compare with other alleles of this locus, while a higher incidence of disease was found
among males who had either allele 12 (C) of DYS388 or allele 14 (E) of DYS439. Moreover, a total of 47 different
haplotypes comprising different alleles of four DYS loci were found among the whole study samples, of which
haplotypes AABC and CAAA showed a lower and higher frequency among cases than controls, respectively.
Conclusions: It is likely that Malaysian males who belong to Y-lineages with either allele 12 of DYS388, allele
14 of DYS439, or haplotype CAAA are more susceptible to develop prostate cancer, while those belonging to
lineages with allele 10 of DYS388 or haplotype AABC are more resistant to the disease. |
| first_indexed | 2024-03-06T07:59:48Z |
| format | Article |
| id | upm.eprints-24419 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:59:48Z |
| publishDate | 2011 |
| publisher | Asian Pacific Organization for Cancer Prevention |
| record_format | dspace |
| spelling | upm.eprints-244192015-12-16T04:32:48Z http://psasir.upm.edu.my/id/eprint/24419/ Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. Nargesi, Mirsaed Miri Ismail, Patimah Abdul Razack, Azad Hassan Pasalar, Parvin Nazemi, Ali Oshkoor, Sima Attaollahi Amini, Peyman Purpose: Prostate cancer differs markedly in incidence across ethnic groups. Since this disease is influenced by complex genetics, it is many genetic factors may affect the level of susceptibility to development of the disease. In this study, four Y-linked short tandem repeats (STRs), DYS388, DYS435, DYS437, and DYS439, were genotyped to compare Malaysian prostate cancer patients and normal control males. Materials and methods: A total of 175 subjects comprising 84 patients and 91 healthy individuals were recruited. Multiplex PCR was optimized to co-amplify DYS388, DYS435, DYS437, and DYS439 loci. All samples were genotyped for alleles of four DYS loci using a Genetic Analysis System. Results: Of all DYS loci, allele 10 (A) of DYS388 had a significantly lower incidence of disease in compare with other alleles of this locus, while a higher incidence of disease was found among males who had either allele 12 (C) of DYS388 or allele 14 (E) of DYS439. Moreover, a total of 47 different haplotypes comprising different alleles of four DYS loci were found among the whole study samples, of which haplotypes AABC and CAAA showed a lower and higher frequency among cases than controls, respectively. Conclusions: It is likely that Malaysian males who belong to Y-lineages with either allele 12 of DYS388, allele 14 of DYS439, or haplotype CAAA are more susceptible to develop prostate cancer, while those belonging to lineages with allele 10 of DYS388 or haplotype AABC are more resistant to the disease. Asian Pacific Organization for Cancer Prevention 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24419/1/Linkage%20between%20prostate%20cancer%20occurrence%20and%20Y.pdf Nargesi, Mirsaed Miri and Ismail, Patimah and Abdul Razack, Azad Hassan and Pasalar, Parvin and Nazemi, Ali and Oshkoor, Sima Attaollahi and Amini, Peyman (2011) Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. Asian Pacific Journal of Cancer Prevention, 12 (5). pp. 1265-1268. ISSN 1513-7368 http://www.apocpcontrol.org/ English |
| spellingShingle | Nargesi, Mirsaed Miri Ismail, Patimah Abdul Razack, Azad Hassan Pasalar, Parvin Nazemi, Ali Oshkoor, Sima Attaollahi Amini, Peyman Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. |
| title | Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. |
| title_full | Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. |
| title_fullStr | Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. |
| title_full_unstemmed | Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. |
| title_short | Linkage between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian subjects.. |
| title_sort | linkage between prostate cancer occurrence and y chromosomal dys loci in malaysian subjects |
| url | http://psasir.upm.edu.my/id/eprint/24419/1/Linkage%20between%20prostate%20cancer%20occurrence%20and%20Y.pdf |
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