n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf.
Ethnopharmacological relevance Bauhinia purpurea (Fabaceae) is a medicinal plant traditionally used to treat various ailments, including ulcers. In order to establish pharmacological properties of the leaf of Bauhinia purpurea, studies were performed on antiulcer activity of the plant's aqueou...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24500/1/n%20vivo%20antiulcer%20activity%20of%20the%20aqueous%20extract%20of%20Bauhinia%20purpurea%20leaf.pdf |
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| author | Zakaria, Zainul Amiruddin Abdul Hisam, E. E. Rofiee, M. S. Mohtarrudin, Norhafizah Somchit, Muhammad Nazrul Teh, L. K. Salleh, M. Z. |
| author_facet | Zakaria, Zainul Amiruddin Abdul Hisam, E. E. Rofiee, M. S. Mohtarrudin, Norhafizah Somchit, Muhammad Nazrul Teh, L. K. Salleh, M. Z. |
| author_sort | Zakaria, Zainul Amiruddin |
| collection | UPM |
| description | Ethnopharmacological relevance
Bauhinia purpurea (Fabaceae) is a medicinal plant traditionally used to treat various ailments, including ulcers. In order to establish pharmacological properties of the leaf of Bauhinia purpurea, studies were performed on antiulcer activity of the plant's aqueous extract.
Materials and methods
The Bauhinia purpurea aqueous extract (BPAE) was prepared in the doses of 100, 500 and 1000 mg/kg. Antiulcer activity of BPAE was evaluated by absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation models. Acute toxicity was also carried out.
Results
BPAE, at the dose of 5000 mg/kg, did not cause any signs of toxicity to rats when given orally. Oral administration of BPAE exhibited antiulcer activity (p < 0.05) in all models used. However, the dose-dependent activity was observed only in the absolute ethanol-induced gastric ulcer model. Histological studies supported the observed antiulcer activity of BPAE. In pyloric ligation assay, BPAE increased the gastric wall mucus secretion.
Conclusions
The BPAE exhibits antiulcer activity, which could be due to the presence of saponins or sugar-free polyphenols, and, thus, confirmed the traditional uses of Bauhinia purpurea in the treatment of ulcers. |
| first_indexed | 2024-03-06T08:00:02Z |
| format | Article |
| id | upm.eprints-24500 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:00:02Z |
| publishDate | 2011 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-245002015-11-24T03:23:40Z http://psasir.upm.edu.my/id/eprint/24500/ n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. Zakaria, Zainul Amiruddin Abdul Hisam, E. E. Rofiee, M. S. Mohtarrudin, Norhafizah Somchit, Muhammad Nazrul Teh, L. K. Salleh, M. Z. Ethnopharmacological relevance Bauhinia purpurea (Fabaceae) is a medicinal plant traditionally used to treat various ailments, including ulcers. In order to establish pharmacological properties of the leaf of Bauhinia purpurea, studies were performed on antiulcer activity of the plant's aqueous extract. Materials and methods The Bauhinia purpurea aqueous extract (BPAE) was prepared in the doses of 100, 500 and 1000 mg/kg. Antiulcer activity of BPAE was evaluated by absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation models. Acute toxicity was also carried out. Results BPAE, at the dose of 5000 mg/kg, did not cause any signs of toxicity to rats when given orally. Oral administration of BPAE exhibited antiulcer activity (p < 0.05) in all models used. However, the dose-dependent activity was observed only in the absolute ethanol-induced gastric ulcer model. Histological studies supported the observed antiulcer activity of BPAE. In pyloric ligation assay, BPAE increased the gastric wall mucus secretion. Conclusions The BPAE exhibits antiulcer activity, which could be due to the presence of saponins or sugar-free polyphenols, and, thus, confirmed the traditional uses of Bauhinia purpurea in the treatment of ulcers. Elsevier 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24500/1/n%20vivo%20antiulcer%20activity%20of%20the%20aqueous%20extract%20of%20Bauhinia%20purpurea%20leaf.pdf Zakaria, Zainul Amiruddin and Abdul Hisam, E. E. and Rofiee, M. S. and Mohtarrudin, Norhafizah and Somchit, Muhammad Nazrul and Teh, L. K. and Salleh, M. Z. (2011) n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. Journal of Ethnopharmacology, 137 (2). pp. 1047-1054. ISSN 0378-8741; ESSN: 1872-7573 10.1016/j.jep.2011.07.038 English |
| spellingShingle | Zakaria, Zainul Amiruddin Abdul Hisam, E. E. Rofiee, M. S. Mohtarrudin, Norhafizah Somchit, Muhammad Nazrul Teh, L. K. Salleh, M. Z. n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. |
| title | n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. |
| title_full | n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. |
| title_fullStr | n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. |
| title_full_unstemmed | n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. |
| title_short | n vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. |
| title_sort | n vivo antiulcer activity of the aqueous extract of bauhinia purpurea leaf |
| url | http://psasir.upm.edu.my/id/eprint/24500/1/n%20vivo%20antiulcer%20activity%20of%20the%20aqueous%20extract%20of%20Bauhinia%20purpurea%20leaf.pdf |
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