In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia.
Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on chloroquineresistant strain of Plasmodium falciparum (FCB strain), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
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Universiti Kebangsaan Malaysia Press
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24559/1/In%20vitro%20antiplasmodial%20activity%20and%20cytotoxicity%20of%20ten%20plants%20used%20as%20traditional%20medicine%20in%20Malaysia.pdf |
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| author | Abdullah, Wan Omar Unyah, Ngah Zasmy Awang Hamat, Rukman Omar, Baharudin Abd Ghani, Mohd Kamel Mohammad Rayani, Hatam, Gholam Reza |
| author_facet | Abdullah, Wan Omar Unyah, Ngah Zasmy Awang Hamat, Rukman Omar, Baharudin Abd Ghani, Mohd Kamel Mohammad Rayani, Hatam, Gholam Reza |
| author_sort | Abdullah, Wan Omar |
| collection | UPM |
| description | Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on chloroquineresistant strain of Plasmodium falciparum (FCB strain), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. Most extracts of ten selected plants used in Malay traditional medicine in Malaysia had activity in vitro. This supports continued investigations of traditional medicine in the search for new antimalarial agent. The compounds responsible for the observed antiplasmodial effects are under investigation.
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| first_indexed | 2024-03-06T08:00:12Z |
| format | Article |
| id | upm.eprints-24559 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:00:12Z |
| publishDate | 2011 |
| publisher | Universiti Kebangsaan Malaysia Press |
| record_format | dspace |
| spelling | upm.eprints-245592015-10-09T00:52:14Z http://psasir.upm.edu.my/id/eprint/24559/ In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. Abdullah, Wan Omar Unyah, Ngah Zasmy Awang Hamat, Rukman Omar, Baharudin Abd Ghani, Mohd Kamel Mohammad Rayani, Hatam, Gholam Reza Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on chloroquineresistant strain of Plasmodium falciparum (FCB strain), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. Most extracts of ten selected plants used in Malay traditional medicine in Malaysia had activity in vitro. This supports continued investigations of traditional medicine in the search for new antimalarial agent. The compounds responsible for the observed antiplasmodial effects are under investigation. Universiti Kebangsaan Malaysia Press 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24559/1/In%20vitro%20antiplasmodial%20activity%20and%20cytotoxicity%20of%20ten%20plants%20used%20as%20traditional%20medicine%20in%20Malaysia.pdf Abdullah, Wan Omar and Unyah, Ngah Zasmy and Awang Hamat, Rukman and Omar, Baharudin and Abd Ghani, Mohd Kamel and Mohammad Rayani, and Hatam, Gholam Reza (2011) In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. Malaysian Journal of Health Science, 9 (2). pp. 5-8. ISSN 1675-8161; ESSN: 2289-4535 http://ejournal.ukm.my/jskm/ English |
| spellingShingle | Abdullah, Wan Omar Unyah, Ngah Zasmy Awang Hamat, Rukman Omar, Baharudin Abd Ghani, Mohd Kamel Mohammad Rayani, Hatam, Gholam Reza In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. |
| title | In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. |
| title_full | In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. |
| title_fullStr | In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. |
| title_full_unstemmed | In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. |
| title_short | In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. |
| title_sort | in vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/24559/1/In%20vitro%20antiplasmodial%20activity%20and%20cytotoxicity%20of%20ten%20plants%20used%20as%20traditional%20medicine%20in%20Malaysia.pdf |
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