The effects of a synthetic curcuminoid analogue,2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatorysignaling pathways and CLP-induced lethal sepsis in mice.

The effects of a synthetic curcuminoid analogue,2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatorysignaling pathways and CLP-induced lethal sepsis in mice.

We previously showed that 2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone (BHMC), suppressed the synthesis of various proinflammatory mediators. In this study we explain the mechanism of action of BHMC in lipopolysaccharide (LPS)-induced U937 monocytes and further show that BHMC prevents leth...

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Bibliographic Details
Main Authors: Chau, Ling Tham, Kok, Wai Lam, Rajajendram, Revathee, Cheah, Yoke Kqueen, Sulaiman, Mohd Roslan, Lajis, Md. Nordin, Kim, Min Kyu, Israf Ali, Daud Ahmad
Format: Article
Language:English
Published: Elsevier 2011
Online Access:http://psasir.upm.edu.my/id/eprint/24568/1/The%20effects%20of%20a%20synthetic%20curcuminoid%20analogue.pdf

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