Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production
Objective: The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism. Materials and Methods: The air-dried, powdered leaves were soak...
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| Format: | Article |
| Language: | English |
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Karger
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24585/1/Bixa%20orellana%20leaves%20extract%20inhibits%20bradykinin.pdf |
| _version_ | 1796970588812607488 |
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| author | Yong, Yoke Keong Abdul Kadir, Arifah Sukardi, Sabrina Abd Hamid @ Abdul Razak, Roslida Somchit, Muhammad Nazrul Ahmad, Zuraini |
| author_facet | Yong, Yoke Keong Abdul Kadir, Arifah Sukardi, Sabrina Abd Hamid @ Abdul Razak, Roslida Somchit, Muhammad Nazrul Ahmad, Zuraini |
| author_sort | Yong, Yoke Keong |
| collection | UPM |
| description | Objective: The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism. Materials and Methods: The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (yield 8.5% w/w). The dosage was recorded as the mass of extract per kg b.w. of rats in all inflammatory assays (bradykinin-induced paw edema, peritoneal vascular permeability and NO assay). Results: Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. In addition, AEBO was also found to significantly suppress the production of NO at doses of 50 and 150 mg/kg. Conclusion: This study provides scientific data to support the traditional use of B. orellana leaves in treating inflammation. Results from this study suggest that AEBO exerts anti-inflammatory effects. Part of this anti-inflammatory effect may be associated with its antibradykinin activity and may be related to a reduction of the NO production. |
| first_indexed | 2024-03-06T08:00:17Z |
| format | Article |
| id | upm.eprints-24585 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:00:17Z |
| publishDate | 2011 |
| publisher | Karger |
| record_format | dspace |
| spelling | upm.eprints-245852016-10-28T03:04:36Z http://psasir.upm.edu.my/id/eprint/24585/ Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production Yong, Yoke Keong Abdul Kadir, Arifah Sukardi, Sabrina Abd Hamid @ Abdul Razak, Roslida Somchit, Muhammad Nazrul Ahmad, Zuraini Objective: The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism. Materials and Methods: The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (yield 8.5% w/w). The dosage was recorded as the mass of extract per kg b.w. of rats in all inflammatory assays (bradykinin-induced paw edema, peritoneal vascular permeability and NO assay). Results: Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. In addition, AEBO was also found to significantly suppress the production of NO at doses of 50 and 150 mg/kg. Conclusion: This study provides scientific data to support the traditional use of B. orellana leaves in treating inflammation. Results from this study suggest that AEBO exerts anti-inflammatory effects. Part of this anti-inflammatory effect may be associated with its antibradykinin activity and may be related to a reduction of the NO production. Karger 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24585/1/Bixa%20orellana%20leaves%20extract%20inhibits%20bradykinin.pdf Yong, Yoke Keong and Abdul Kadir, Arifah and Sukardi, Sabrina and Abd Hamid @ Abdul Razak, Roslida and Somchit, Muhammad Nazrul and Ahmad, Zuraini (2011) Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production. Medical Principles and Practice, 20 (2). pp. 142-146. ISSN 1011-7571; ESSN: 1423-0151 http://www.karger.com/Article/Abstract/319907 10.1159/000319907 |
| spellingShingle | Yong, Yoke Keong Abdul Kadir, Arifah Sukardi, Sabrina Abd Hamid @ Abdul Razak, Roslida Somchit, Muhammad Nazrul Ahmad, Zuraini Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production |
| title | Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production |
| title_full | Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production |
| title_fullStr | Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production |
| title_full_unstemmed | Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production |
| title_short | Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production |
| title_sort | bixa orellana leaves extract inhibits bradykinin induced inflammation through suppression of nitric oxide production |
| url | http://psasir.upm.edu.my/id/eprint/24585/1/Bixa%20orellana%20leaves%20extract%20inhibits%20bradykinin.pdf |
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