Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite.
The intercalation of perindopril erbumine into Zn/Al-NO3-layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was released in a sustained manner. Therefore, this intercalated mat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Dove Medical Press
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24618/1/Controlled%20release%20and%20angiotensin.pdf |
| _version_ | 1825925607943307264 |
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| author | Hussein Al Ali, Samer Hasan Al-Qubaisi, Mothanna Hussein, Mohd Zobir Ismail, Maznah Zainal, Zulkarnain Abdullah, Muhammad Nazrul Hakim |
| author_facet | Hussein Al Ali, Samer Hasan Al-Qubaisi, Mothanna Hussein, Mohd Zobir Ismail, Maznah Zainal, Zulkarnain Abdullah, Muhammad Nazrul Hakim |
| author_sort | Hussein Al Ali, Samer Hasan |
| collection | UPM |
| description | The intercalation of perindopril erbumine into Zn/Al-NO3-layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was released in a sustained manner. Therefore, this intercalated material can be used as a controlled-release formulation. Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 Å and 19.9 Å by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril. Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-release properties and can therefore be used as a controlled-release formulation. |
| first_indexed | 2024-03-06T08:00:23Z |
| format | Article |
| id | upm.eprints-24618 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:00:23Z |
| publishDate | 2012 |
| publisher | Dove Medical Press |
| record_format | dspace |
| spelling | upm.eprints-246182015-09-14T00:05:49Z http://psasir.upm.edu.my/id/eprint/24618/ Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. Hussein Al Ali, Samer Hasan Al-Qubaisi, Mothanna Hussein, Mohd Zobir Ismail, Maznah Zainal, Zulkarnain Abdullah, Muhammad Nazrul Hakim The intercalation of perindopril erbumine into Zn/Al-NO3-layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was released in a sustained manner. Therefore, this intercalated material can be used as a controlled-release formulation. Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 Å and 19.9 Å by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril. Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-release properties and can therefore be used as a controlled-release formulation. Dove Medical Press 2012 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24618/1/Controlled%20release%20and%20angiotensin.pdf Hussein Al Ali, Samer Hasan and Al-Qubaisi, Mothanna and Hussein, Mohd Zobir and Ismail, Maznah and Zainal, Zulkarnain and Abdullah, Muhammad Nazrul Hakim (2012) Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. International Journal of Nanomedicine, 7 (1). pp. 2129-2141. ISSN 1176-9114; ESSN:1178-2013 http://www.dovepress.com/ 10.2147/IJN.S30461 English |
| spellingShingle | Hussein Al Ali, Samer Hasan Al-Qubaisi, Mothanna Hussein, Mohd Zobir Ismail, Maznah Zainal, Zulkarnain Abdullah, Muhammad Nazrul Hakim Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. |
| title | Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. |
| title_full | Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. |
| title_fullStr | Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. |
| title_full_unstemmed | Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. |
| title_short | Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. |
| title_sort | controlled release and angiotensin converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine layered double hydroxide nanocomposite |
| url | http://psasir.upm.edu.my/id/eprint/24618/1/Controlled%20release%20and%20angiotensin.pdf |
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