Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and â-catenin and enhances invasion in nasopharyngeal carcinoma cells.
Dysregulation of E-cadherin and β-catenin function in cell-cell adhesion is common in nasopharyngeal carcinoma (NPC) and correlates with metastatic disease. In this study, we examined the role of EGF-activated phosphatidylinositol 3-kinase (PI3K)-Akt signaling in E-cadherin and β-catenin regulation....
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24623/1/Activation%20of%20phosphatidylinositol%203.pdf |