The heritability of premenstrual syndrome
We aimed to determine (1) the prevalence of premenstrual syndrome in a sample of twins and (2) the relative contribution of genes and environment in premenstrual syndrome. A group of 193 subjects inclusive of same gender twins (n = 176) and females from opposite sex twin sets (n = 17) entered the st...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24674/1/The%20heritability%20of%20premenstrual%20syndrome.pdf |
| _version_ | 1796970606585970688 |
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| author | Jahanfar, Shayesteh Lye, Munn Sann S. Krishnarajah, Isthrinayagy |
| author_facet | Jahanfar, Shayesteh Lye, Munn Sann S. Krishnarajah, Isthrinayagy |
| author_sort | Jahanfar, Shayesteh |
| collection | UPM |
| description | We aimed to determine (1) the prevalence of premenstrual syndrome in a sample of twins and (2) the relative contribution of genes and environment in premenstrual syndrome. A group of 193 subjects inclusive of same gender twins (n = 176) and females from opposite sex twin sets (n = 17) entered the study. Heritability analysis used same gender twin data only. The probandwise concordance rate for the presence or absence of premenstrual syndrome was calculated and the heritability of premenstrual syndrome was assessed by a quantitative genetic model fitting approach using MX software. The prevalence of premenstrual syndrome was 43.0% and 46.8% in monozygotic and dizygotic twins, respectively. The probandwise concordance for premenstrual syndrome was higher in monozygotic (0.81) than in dizygotic twins (0.67), indicating a strong genetic effect. Quantitative genetic modeling found that a model comprising of additive genetic (A) and unique environment (E) factors provided the best fit (A: 95%, E: 5%). No association was found between premenstrual symptom and the following variables: belonging to the opposite gender twin set, birth weight, being breast fed and vaccination. These results established a clear genetic influence in premenstrual syndrome. |
| first_indexed | 2024-03-06T08:00:33Z |
| format | Article |
| id | upm.eprints-24674 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:00:33Z |
| publishDate | 2011 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | upm.eprints-246742018-10-16T02:16:28Z http://psasir.upm.edu.my/id/eprint/24674/ The heritability of premenstrual syndrome Jahanfar, Shayesteh Lye, Munn Sann S. Krishnarajah, Isthrinayagy We aimed to determine (1) the prevalence of premenstrual syndrome in a sample of twins and (2) the relative contribution of genes and environment in premenstrual syndrome. A group of 193 subjects inclusive of same gender twins (n = 176) and females from opposite sex twin sets (n = 17) entered the study. Heritability analysis used same gender twin data only. The probandwise concordance rate for the presence or absence of premenstrual syndrome was calculated and the heritability of premenstrual syndrome was assessed by a quantitative genetic model fitting approach using MX software. The prevalence of premenstrual syndrome was 43.0% and 46.8% in monozygotic and dizygotic twins, respectively. The probandwise concordance for premenstrual syndrome was higher in monozygotic (0.81) than in dizygotic twins (0.67), indicating a strong genetic effect. Quantitative genetic modeling found that a model comprising of additive genetic (A) and unique environment (E) factors provided the best fit (A: 95%, E: 5%). No association was found between premenstrual symptom and the following variables: belonging to the opposite gender twin set, birth weight, being breast fed and vaccination. These results established a clear genetic influence in premenstrual syndrome. Cambridge University Press 2011-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/24674/1/The%20heritability%20of%20premenstrual%20syndrome.pdf Jahanfar, Shayesteh and Lye, Munn Sann and S. Krishnarajah, Isthrinayagy (2011) The heritability of premenstrual syndrome. Twin Research and Human Genetics, 14 (5). pp. 433-436. ISSN 1832-4274; ESSN: 1839-2628 https://www.cambridge.org/core/journals/twin-research-and-human-genetics/article/heritability-of-premenstrual-syndrome/1B0D2436B3983ED4F80F191B99C1ACCD 10.1375/twin.14.5.433 |
| spellingShingle | Jahanfar, Shayesteh Lye, Munn Sann S. Krishnarajah, Isthrinayagy The heritability of premenstrual syndrome |
| title | The heritability of premenstrual syndrome |
| title_full | The heritability of premenstrual syndrome |
| title_fullStr | The heritability of premenstrual syndrome |
| title_full_unstemmed | The heritability of premenstrual syndrome |
| title_short | The heritability of premenstrual syndrome |
| title_sort | heritability of premenstrual syndrome |
| url | http://psasir.upm.edu.my/id/eprint/24674/1/The%20heritability%20of%20premenstrual%20syndrome.pdf |
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