In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil.
Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by theMalaysian Agriculture Research and Development Institute (MARDI) using various in vivo models. Materials and Methods: Two types of VCOs, produce...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
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Karger: Open Access Journals
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24728/1/In%20vivo%20antinociceptive%20and%20anti.pdf |
| _version_ | 1796970617698779136 |
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| author | Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul Mat Jais, Abdul Manan Lay, Kek Teh Salleh, Mohd Zaki Long, Kamariah Abdullah, Muhammad Nazrul Hakim |
| author_facet | Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul Mat Jais, Abdul Manan Lay, Kek Teh Salleh, Mohd Zaki Long, Kamariah Abdullah, Muhammad Nazrul Hakim |
| author_sort | Zakaria, Zainul Amiruddin |
| collection | UPM |
| description | Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by theMalaysian Agriculture Research and Development Institute (MARDI) using various in vivo models. Materials and Methods: Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of both VCOs were examined using various in vivomodel systems. The antinociceptive activity of the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5 mg/kg) and/or acetylsalicylic acid (100 mg/kg). Results: Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05) antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test), but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation. Conclusion: The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further studies are needed to confirm these observations. |
| first_indexed | 2024-03-06T08:00:43Z |
| format | Article |
| id | upm.eprints-24728 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:00:43Z |
| publishDate | 2011 |
| publisher | Karger: Open Access Journals |
| record_format | dspace |
| spelling | upm.eprints-247282015-11-18T03:15:04Z http://psasir.upm.edu.my/id/eprint/24728/ In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul Mat Jais, Abdul Manan Lay, Kek Teh Salleh, Mohd Zaki Long, Kamariah Abdullah, Muhammad Nazrul Hakim Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by theMalaysian Agriculture Research and Development Institute (MARDI) using various in vivo models. Materials and Methods: Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of both VCOs were examined using various in vivomodel systems. The antinociceptive activity of the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5 mg/kg) and/or acetylsalicylic acid (100 mg/kg). Results: Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05) antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test), but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation. Conclusion: The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further studies are needed to confirm these observations. Karger: Open Access Journals 2011-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24728/1/In%20vivo%20antinociceptive%20and%20anti.pdf Zakaria, Zainul Amiruddin and Somchit, Muhammad Nazrul and Mat Jais, Abdul Manan and Lay, Kek Teh and Salleh, Mohd Zaki and Long, Kamariah and Abdullah, Muhammad Nazrul Hakim (2011) In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. Medical Principles and Practice, 20 (3). pp. 231-236. ISSN 1011-7571; ESSN:1423-0151 http://www.karger.com/ 10.1159/000323756 English |
| spellingShingle | Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul Mat Jais, Abdul Manan Lay, Kek Teh Salleh, Mohd Zaki Long, Kamariah Abdullah, Muhammad Nazrul Hakim In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. |
| title | In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. |
| title_full | In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. |
| title_fullStr | In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. |
| title_full_unstemmed | In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. |
| title_short | In vivo antinociceptive and anti-inflammatory activities of dried- and fermented-processed virgin coconut oil. |
| title_sort | in vivo antinociceptive and anti inflammatory activities of dried and fermented processed virgin coconut oil |
| url | http://psasir.upm.edu.my/id/eprint/24728/1/In%20vivo%20antinociceptive%20and%20anti.pdf |
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