Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus.

An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human prom...

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Detalhes bibliográficos
Principais autores: Mohd Hashim, Najihah, Rahmani, Mawardi, Ee, Gwendoline Cheng Lian, Md.Sukari, Mohd. Aspollah, Yahayu, Maizatulakmal, Oktima, Winda, Ali, Abd Manaf, Go, Rusea
Formato: Artigo
Idioma:English
English
Publicado em: Hindawi Publishing Corporation 2012
Acesso em linha:http://psasir.upm.edu.my/id/eprint/24942/1/Antiproliferative%20Activity%20of%20Xanthones%20Isolated%20from%20Artocarpus%20obtusus.pdf
Descrição
Resumo:An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC 50 values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC 50 values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC 50 values of more than 30 μg/mL.