An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives.
Heat-sensitive bioactive compounds such as β-carotene and tocols, are widely used in the pharmaceutical and cosmetic fields. Their chemical stability in delivery systems is one of the major concerns in the production of nanostructured lipid carriers (NLCs). A previously established high-temperature...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2011
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/24950/1/An%20improved%20method%20for%20the%20preparations%20of%20nanostructured%20lipid%20carriers%20containing%20heat.pdf |
| _version_ | 1825925677491159040 |
|---|---|
| author | Loo, Chew Hung Basri, Mahiran Tejo, Bimo Ario Ismail, Rosnah Lau, Harrison Lik Nang Abu Hassan, Hazimah Choo , Yuen May |
| author_facet | Loo, Chew Hung Basri, Mahiran Tejo, Bimo Ario Ismail, Rosnah Lau, Harrison Lik Nang Abu Hassan, Hazimah Choo , Yuen May |
| author_sort | Loo, Chew Hung |
| collection | UPM |
| description | Heat-sensitive bioactive compounds such as β-carotene and tocols, are widely used in the pharmaceutical and cosmetic fields. Their chemical stability in delivery systems is one of the major concerns in the production of nanostructured lipid carriers (NLCs). A previously established high-temperature high-pressure homogenisation technique involved in the preparation of NLCs can cause degradation of heat-sensitive compounds. Therefore, a novel preparation process needs to be developed to minimise the degradation of heat-sensitive active compounds during the preparation of NLCs. In this work, modified methods A and B were designed to minimise the degradation of β-carotene and tocols during the production of NLCs. These methods improved the chemical stability of heat-sensitive bioactive compounds (β-carotene and tocols) significantly compared to the previously established method. The physical stability of the formulation was maintained throughout study duration. |
| first_indexed | 2024-03-06T08:01:22Z |
| format | Article |
| id | upm.eprints-24950 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:01:22Z |
| publishDate | 2011 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-249502015-10-05T02:59:20Z http://psasir.upm.edu.my/id/eprint/24950/ An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. Loo, Chew Hung Basri, Mahiran Tejo, Bimo Ario Ismail, Rosnah Lau, Harrison Lik Nang Abu Hassan, Hazimah Choo , Yuen May Heat-sensitive bioactive compounds such as β-carotene and tocols, are widely used in the pharmaceutical and cosmetic fields. Their chemical stability in delivery systems is one of the major concerns in the production of nanostructured lipid carriers (NLCs). A previously established high-temperature high-pressure homogenisation technique involved in the preparation of NLCs can cause degradation of heat-sensitive compounds. Therefore, a novel preparation process needs to be developed to minimise the degradation of heat-sensitive active compounds during the preparation of NLCs. In this work, modified methods A and B were designed to minimise the degradation of β-carotene and tocols during the production of NLCs. These methods improved the chemical stability of heat-sensitive bioactive compounds (β-carotene and tocols) significantly compared to the previously established method. The physical stability of the formulation was maintained throughout study duration. Elsevier 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24950/1/An%20improved%20method%20for%20the%20preparations%20of%20nanostructured%20lipid%20carriers%20containing%20heat.pdf Loo, Chew Hung and Basri, Mahiran and Tejo, Bimo Ario and Ismail, Rosnah and Lau, Harrison Lik Nang and Abu Hassan, Hazimah and Choo , Yuen May (2011) An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. Colloids and Surfaces B: Biointerfaces, 87 (1). pp. 180-186. ISSN 0927-7765; ESSN:1873-4367 http://www.elsevier.com/ 10.1016/j.colsurfb.2011.05.019 English |
| spellingShingle | Loo, Chew Hung Basri, Mahiran Tejo, Bimo Ario Ismail, Rosnah Lau, Harrison Lik Nang Abu Hassan, Hazimah Choo , Yuen May An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. |
| title | An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. |
| title_full | An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. |
| title_fullStr | An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. |
| title_full_unstemmed | An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. |
| title_short | An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. |
| title_sort | improved method for the preparations of nanostructured lipid carriers containing heat sensitive bioactives |
| url | http://psasir.upm.edu.my/id/eprint/24950/1/An%20improved%20method%20for%20the%20preparations%20of%20nanostructured%20lipid%20carriers%20containing%20heat.pdf |
| work_keys_str_mv | AT loochewhung animprovedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT basrimahiran animprovedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT tejobimoario animprovedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT ismailrosnah animprovedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT lauharrisonliknang animprovedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT abuhassanhazimah animprovedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT chooyuenmay animprovedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT loochewhung improvedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT basrimahiran improvedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT tejobimoario improvedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT ismailrosnah improvedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT lauharrisonliknang improvedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT abuhassanhazimah improvedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives AT chooyuenmay improvedmethodforthepreparationsofnanostructuredlipidcarrierscontainingheatsensitivebioactives |