Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data.
In population based cancer clinical trials, a proportion of patients will never experience the interested event and considered as "cured" or "immunes". The majority of recent cancer studies focus on the estimation of immune proportion. In this study we investigated the estimation...
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| Format: | Article |
| Language: | English English |
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Asian Network for Scientific Information
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25131/1/Parametric%20estimation%20of%20the%20immunes%20proportion%20based%20on%20BCH%20model%20and%20exponential%20distribution%20using%20left%20censored%20data.pdf |
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| author | I. Aljawadi, Bader Ahmad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah |
| author_facet | I. Aljawadi, Bader Ahmad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah |
| author_sort | I. Aljawadi, Bader Ahmad |
| collection | UPM |
| description | In population based cancer clinical trials, a proportion of patients will never experience the interested event and considered as "cured" or "immunes". The majority of recent cancer studies focus on the estimation of immune proportion. In this study we investigated the estimation of proportion of patients curd of cancer in case of left censored data based on the Bounded Cumulative Hazard (BCH) model proposed by Chen in 1999. The analysis provided the Maximum Likelihood Estimation (MLE) of the parameters within the framework of the Expectation Maximization (EM) algorithm where the numerical solutions of the estimation equations of the cure rate parameter could be employed. |
| first_indexed | 2024-03-06T08:01:55Z |
| format | Article |
| id | upm.eprints-25131 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:01:55Z |
| publishDate | 2011 |
| publisher | Asian Network for Scientific Information |
| record_format | dspace |
| spelling | upm.eprints-251312015-09-23T03:22:31Z http://psasir.upm.edu.my/id/eprint/25131/ Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. I. Aljawadi, Bader Ahmad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah In population based cancer clinical trials, a proportion of patients will never experience the interested event and considered as "cured" or "immunes". The majority of recent cancer studies focus on the estimation of immune proportion. In this study we investigated the estimation of proportion of patients curd of cancer in case of left censored data based on the Bounded Cumulative Hazard (BCH) model proposed by Chen in 1999. The analysis provided the Maximum Likelihood Estimation (MLE) of the parameters within the framework of the Expectation Maximization (EM) algorithm where the numerical solutions of the estimation equations of the cure rate parameter could be employed. Asian Network for Scientific Information 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25131/1/Parametric%20estimation%20of%20the%20immunes%20proportion%20based%20on%20BCH%20model%20and%20exponential%20distribution%20using%20left%20censored%20data.pdf I. Aljawadi, Bader Ahmad and Abu Bakar, Mohd Rizam and Ibrahim, Noor Akma and Midi, Habshah (2011) Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. Journal of Applied Sciences, 11 (15). pp. 2861-2865. ISSN 1812-5654 http://www.ansinet.com/ 10.3923/jas.2011.2861.2865 English |
| spellingShingle | I. Aljawadi, Bader Ahmad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. |
| title | Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. |
| title_full | Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. |
| title_fullStr | Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. |
| title_full_unstemmed | Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. |
| title_short | Parametric estimation of the immunes proportion based on BCH model and exponential distribution using left censored data. |
| title_sort | parametric estimation of the immunes proportion based on bch model and exponential distribution using left censored data |
| url | http://psasir.upm.edu.my/id/eprint/25131/1/Parametric%20estimation%20of%20the%20immunes%20proportion%20based%20on%20BCH%20model%20and%20exponential%20distribution%20using%20left%20censored%20data.pdf |
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