Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents
Magnetite (Fe3O4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl2·4H2O and FeCl3 with NaOH as reducing agent to initiate the precipitation of F...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25173/1/Hydrothermal%20synthesis%20of%20magnetite%20nanoparticles%20as%20MRI%20contrast%20agents.pdf |
| _version_ | 1796970706181816320 |
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| author | Haw, Choon Yian Mohamed, Faizal Chia, Chin Hua Radiman, Shahidan Zakaria, Sarani Huang, Nay Ming Lim, Hong Ngee |
| author_facet | Haw, Choon Yian Mohamed, Faizal Chia, Chin Hua Radiman, Shahidan Zakaria, Sarani Huang, Nay Ming Lim, Hong Ngee |
| author_sort | Haw, Choon Yian |
| collection | UPM |
| description | Magnetite (Fe3O4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl2·4H2O and FeCl3 with NaOH as reducing agent to initiate the precipitation of Fe3O4, followed by hydrothermal treatment to produce nano-sized Fe3O4. Chitosan (CTS) was coated onto the surface of the as-prepared Fe3O4 nanoparticles to enhance its stability and biocompatible properties. The size distribution of the obtained Fe3O4 nanoparticles was examined using transmission electron microscopy (TEM). The cubic inverse spinel structure of Fe3O4 nanoparticles was confirmed by X-ray diffraction technique (XRD). Fourier transform infrared (FTIR) spectrum indicated the presence of the chitosan on the surface of the Fe3O4 nanoparticles. The superparamagnetic behaviour of the produced Fe3O4 nanoparticles at room temperature was elucidated using a vibrating sample magnetometer (VSM). From the result of custom made phantom study of magnetic resonance (MR) imaging, coated Fe3O4 nanoparticles have been proved to be a promising contrast enhanced agent in MR imaging. |
| first_indexed | 2024-03-06T08:02:03Z |
| format | Article |
| id | upm.eprints-25173 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:02:03Z |
| publishDate | 2010 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-251732016-03-03T13:38:02Z http://psasir.upm.edu.my/id/eprint/25173/ Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents Haw, Choon Yian Mohamed, Faizal Chia, Chin Hua Radiman, Shahidan Zakaria, Sarani Huang, Nay Ming Lim, Hong Ngee Magnetite (Fe3O4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl2·4H2O and FeCl3 with NaOH as reducing agent to initiate the precipitation of Fe3O4, followed by hydrothermal treatment to produce nano-sized Fe3O4. Chitosan (CTS) was coated onto the surface of the as-prepared Fe3O4 nanoparticles to enhance its stability and biocompatible properties. The size distribution of the obtained Fe3O4 nanoparticles was examined using transmission electron microscopy (TEM). The cubic inverse spinel structure of Fe3O4 nanoparticles was confirmed by X-ray diffraction technique (XRD). Fourier transform infrared (FTIR) spectrum indicated the presence of the chitosan on the surface of the Fe3O4 nanoparticles. The superparamagnetic behaviour of the produced Fe3O4 nanoparticles at room temperature was elucidated using a vibrating sample magnetometer (VSM). From the result of custom made phantom study of magnetic resonance (MR) imaging, coated Fe3O4 nanoparticles have been proved to be a promising contrast enhanced agent in MR imaging. Elsevier 2010-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25173/1/Hydrothermal%20synthesis%20of%20magnetite%20nanoparticles%20as%20MRI%20contrast%20agents.pdf Haw, Choon Yian and Mohamed, Faizal and Chia, Chin Hua and Radiman, Shahidan and Zakaria, Sarani and Huang, Nay Ming and Lim, Hong Ngee (2010) Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents. Ceramics International, 36 (4). pp. 1417-1422. ISSN 0272-8842; ESSN: 1873-3956 http://www.sciencedirect.com/science/article/pii/S0272884210000611 10.1016/j.ceramint.2010.02.005 |
| spellingShingle | Haw, Choon Yian Mohamed, Faizal Chia, Chin Hua Radiman, Shahidan Zakaria, Sarani Huang, Nay Ming Lim, Hong Ngee Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents |
| title | Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents |
| title_full | Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents |
| title_fullStr | Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents |
| title_full_unstemmed | Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents |
| title_short | Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents |
| title_sort | hydrothermal synthesis of magnetite nanoparticles as mri contrast agents |
| url | http://psasir.upm.edu.my/id/eprint/25173/1/Hydrothermal%20synthesis%20of%20magnetite%20nanoparticles%20as%20MRI%20contrast%20agents.pdf |
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