Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously.
A new monophasic nanohybrid containing two phenoxyherbicides anions, 4-(2,4-dichlorophenoxy)butyrate (DPBA) and 2-(3-chlorophenoxy)propionate (CPPA), was successfully synthesized. The two anions were simultaneously intercalated into the inorganic interlayers of zinc-aluminum-layered double hydroxide...
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| Format: | Article |
| Language: | English English |
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Elsevier
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25283/1/Synthesis%20of%20a%20monophasic%20nanohybrid%20for%20a%20controlled%20release%20formulation%20of%20two%20active%20agents%20simultaneously.pdf |
| _version_ | 1796970728133754880 |
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| author | Hussein, Mohd. Zobir Abdul Rahman, Nor Shazlirah Shazlyn Sarijo, Siti Halimah Zainal, Zulkarnain |
| author_facet | Hussein, Mohd. Zobir Abdul Rahman, Nor Shazlirah Shazlyn Sarijo, Siti Halimah Zainal, Zulkarnain |
| author_sort | Hussein, Mohd. Zobir |
| collection | UPM |
| description | A new monophasic nanohybrid containing two phenoxyherbicides anions, 4-(2,4-dichlorophenoxy)butyrate (DPBA) and 2-(3-chlorophenoxy)propionate (CPPA), was successfully synthesized. The two anions were simultaneously intercalated into the inorganic interlayers of zinc-aluminum-layered double hydroxide (ZAL) for the formation of a nanohybrid, ZAL-CPPA-DPBA (NCDX) by an anion-exchange method. Powder X-ray diffraction, direct-injection mass spectrometry and Fourier transform infrared spectroscopy studies confirmed the dual intercalation of both anions into the host interlayer regions. The well-ordered, layered nanohybrid was synthesized using 0.1. M solution of both anions. The basal spacing expanded from 8.9. Å in ZAL to 27.43. Å in the nanohybrid. The release of both anions from the nanohybrid into an aqueous solution of 0.001. M sodium carbonate was found to be governed by pseudo second-order kinetics. This release demonstrates the potential application of layered materials as reservoirs and delivery system, especially when multiple active agents are used simultaneously in the formation of an organic-inorganic host-guest nanohybrid with controlled-release properties. |
| first_indexed | 2024-03-06T08:02:22Z |
| format | Article |
| id | upm.eprints-25283 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:02:22Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-252832015-09-13T23:57:12Z http://psasir.upm.edu.my/id/eprint/25283/ Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. Hussein, Mohd. Zobir Abdul Rahman, Nor Shazlirah Shazlyn Sarijo, Siti Halimah Zainal, Zulkarnain A new monophasic nanohybrid containing two phenoxyherbicides anions, 4-(2,4-dichlorophenoxy)butyrate (DPBA) and 2-(3-chlorophenoxy)propionate (CPPA), was successfully synthesized. The two anions were simultaneously intercalated into the inorganic interlayers of zinc-aluminum-layered double hydroxide (ZAL) for the formation of a nanohybrid, ZAL-CPPA-DPBA (NCDX) by an anion-exchange method. Powder X-ray diffraction, direct-injection mass spectrometry and Fourier transform infrared spectroscopy studies confirmed the dual intercalation of both anions into the host interlayer regions. The well-ordered, layered nanohybrid was synthesized using 0.1. M solution of both anions. The basal spacing expanded from 8.9. Å in ZAL to 27.43. Å in the nanohybrid. The release of both anions from the nanohybrid into an aqueous solution of 0.001. M sodium carbonate was found to be governed by pseudo second-order kinetics. This release demonstrates the potential application of layered materials as reservoirs and delivery system, especially when multiple active agents are used simultaneously in the formation of an organic-inorganic host-guest nanohybrid with controlled-release properties. Elsevier 2012-04 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25283/1/Synthesis%20of%20a%20monophasic%20nanohybrid%20for%20a%20controlled%20release%20formulation%20of%20two%20active%20agents%20simultaneously.pdf Hussein, Mohd. Zobir and Abdul Rahman, Nor Shazlirah Shazlyn and Sarijo, Siti Halimah and Zainal, Zulkarnain (2012) Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. Applied Clay Science, 58 (1). pp. 60-66. ISSN 0169-1317 10.1016/j.clay.2012.01.012 English |
| spellingShingle | Hussein, Mohd. Zobir Abdul Rahman, Nor Shazlirah Shazlyn Sarijo, Siti Halimah Zainal, Zulkarnain Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. |
| title | Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. |
| title_full | Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. |
| title_fullStr | Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. |
| title_full_unstemmed | Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. |
| title_short | Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously. |
| title_sort | synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously |
| url | http://psasir.upm.edu.my/id/eprint/25283/1/Synthesis%20of%20a%20monophasic%20nanohybrid%20for%20a%20controlled%20release%20formulation%20of%20two%20active%20agents%20simultaneously.pdf |
| work_keys_str_mv | AT husseinmohdzobir synthesisofamonophasicnanohybridforacontrolledreleaseformulationoftwoactiveagentssimultaneously AT abdulrahmannorshazlirahshazlyn synthesisofamonophasicnanohybridforacontrolledreleaseformulationoftwoactiveagentssimultaneously AT sarijositihalimah synthesisofamonophasicnanohybridforacontrolledreleaseformulationoftwoactiveagentssimultaneously AT zainalzulkarnain synthesisofamonophasicnanohybridforacontrolledreleaseformulationoftwoactiveagentssimultaneously |