Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats
The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors thought to act as receptors for polyunsaturated fatty acids and to reduce production of series 2 prostaglandins (PG). The objective of this study was to investigate the effect of different ratio n-6...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Academic Journals
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25333/1/25333.pdf |
| _version_ | 1796970737869783040 |
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| author | Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin |
| author_facet | Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin |
| author_sort | Ali, Amira Abdulbari |
| collection | UPM |
| description | The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors thought to act as receptors for polyunsaturated fatty acids and to reduce production of series 2 prostaglandins (PG). The objective of this study was to investigate the effect of different ratio n-6: n-3 on the PPAR expression of rats endometrial tissue. The findings obtained from this study showed
significant induction of PPARδ mRNA levels in endomatral cells treatment 1:1 group by 1.38 fold compared with the PPARδ mRNA levels in endomatral cells treatment 30:1 group. This induction was due to the cellular demands for prostaglandin were high in the endometrial cells
when cells were treated with high ratio n6:n3 on 30:1 group, thus, resulting in an increase in both prostaglandin
PGE2 and PGF2α production by induction of PPARδ genes. On the other hand, treatment 1:1 group and control group of endometrial cells did not show any significant changes in mRNA level of PPARδ, compared with treatment ratio n6:n3 on 6:1 group and treatment high ratio n6:n3 on 30:1 group of the endometrial cells. These findings show that inhibit
ion of uterine PGF2α synthesis by n-3 fatty acids may
depend on the amount of n-6 fatty acids reaching the target tissue. In conclusion, PPARδ function in the response of rat endometrium to long chain n-6:n3 polyunsaturated fatty acids. |
| first_indexed | 2024-03-06T08:02:31Z |
| format | Article |
| id | upm.eprints-25333 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:02:31Z |
| publishDate | 2011 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | upm.eprints-253332016-11-23T04:15:59Z http://psasir.upm.edu.my/id/eprint/25333/ Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors thought to act as receptors for polyunsaturated fatty acids and to reduce production of series 2 prostaglandins (PG). The objective of this study was to investigate the effect of different ratio n-6: n-3 on the PPAR expression of rats endometrial tissue. The findings obtained from this study showed significant induction of PPARδ mRNA levels in endomatral cells treatment 1:1 group by 1.38 fold compared with the PPARδ mRNA levels in endomatral cells treatment 30:1 group. This induction was due to the cellular demands for prostaglandin were high in the endometrial cells when cells were treated with high ratio n6:n3 on 30:1 group, thus, resulting in an increase in both prostaglandin PGE2 and PGF2α production by induction of PPARδ genes. On the other hand, treatment 1:1 group and control group of endometrial cells did not show any significant changes in mRNA level of PPARδ, compared with treatment ratio n6:n3 on 6:1 group and treatment high ratio n6:n3 on 30:1 group of the endometrial cells. These findings show that inhibit ion of uterine PGF2α synthesis by n-3 fatty acids may depend on the amount of n-6 fatty acids reaching the target tissue. In conclusion, PPARδ function in the response of rat endometrium to long chain n-6:n3 polyunsaturated fatty acids. Academic Journals 2011-08-15 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25333/1/25333.pdf Ali, Amira Abdulbari and Abu Bakar @ Zakaria, Md Zuki and Goh, Yong Meng and Mohamed Mustapha, Noordin (2011) Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats. African Journal of Biotechnology, 10 (44). art. no. 2B2382729852. pp. 8703-8708. ISSN 1684–5315 http://www.academicjournals.org/journal/AJB/article-abstract/2B2382729852 |
| spellingShingle | Ali, Amira Abdulbari Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Mohamed Mustapha, Noordin Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats |
| title | Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats |
| title_full | Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats |
| title_fullStr | Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats |
| title_full_unstemmed | Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats |
| title_short | Effect of dietary n-6 to n-3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator-activated receptor (PPAR) in pregnant Sprague Dawley rats |
| title_sort | effect of dietary n 6 to n 3 polyunsaturated fatty acid ratio on prostaglandin plasma levels and genes expression peroxisome proliferator activated receptor ppar in pregnant sprague dawley rats |
| url | http://psasir.upm.edu.my/id/eprint/25333/1/25333.pdf |
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