Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attenti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Science Publications
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/27056/1/Tamoxifen%20drug%20loading%20solid%20lipid%20nanoparticles%20prepared%20by%20hot%20high%20pressure%20homogenization%20techniques.pdf |
| _version_ | 1825947053925072896 |
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| author | Abdullah Al-Haj, Nagi Ahmed Abdullah, Rasedee Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam |
| author_facet | Abdullah Al-Haj, Nagi Ahmed Abdullah, Rasedee Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam |
| author_sort | Abdullah Al-Haj, Nagi Ahmed |
| collection | UPM |
| description | As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attention as alternative drug delivery carrier. In this study Solid Lipid Nanoparticles (SLNs) containing tamoxifen, nonsteroidal antiestrogens have been loaded and to be used as breast cancer therapy, were prepared by hot High Pressure Homogenization techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. Preliminary study of antiproliferative activity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. SLN was characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM), Zeta Potential and Particle Size. The results of characterization studies strongly support the potential application of Tamoxifen-loaded SLNs as a carrier system. The SLN presented here are well suited for certain drug delivery applications, particularly breast cancer therapy. |
| first_indexed | 2024-03-06T08:07:19Z |
| format | Article |
| id | upm.eprints-27056 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:07:19Z |
| publishDate | 2008 |
| publisher | Science Publications |
| record_format | dspace |
| spelling | upm.eprints-270562015-12-07T03:48:18Z http://psasir.upm.edu.my/id/eprint/27056/ Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. Abdullah Al-Haj, Nagi Ahmed Abdullah, Rasedee Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attention as alternative drug delivery carrier. In this study Solid Lipid Nanoparticles (SLNs) containing tamoxifen, nonsteroidal antiestrogens have been loaded and to be used as breast cancer therapy, were prepared by hot High Pressure Homogenization techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. Preliminary study of antiproliferative activity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. SLN was characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM), Zeta Potential and Particle Size. The results of characterization studies strongly support the potential application of Tamoxifen-loaded SLNs as a carrier system. The SLN presented here are well suited for certain drug delivery applications, particularly breast cancer therapy. Science Publications 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/27056/1/Tamoxifen%20drug%20loading%20solid%20lipid%20nanoparticles%20prepared%20by%20hot%20high%20pressure%20homogenization%20techniques.pdf Abdullah Al-Haj, Nagi Ahmed and Abdullah, Rasedee and Abdelwahab, Siddig Ibrahim and Abdul, Ahmad Bustamam (2008) Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. American Journal of Pharmacology and Toxicology, 3 (3). pp. 219-224. ISSN 1557-4962; ESSN: 1557-4970 10.3844/ajptsp.2008.219.224 English |
| spellingShingle | Abdullah Al-Haj, Nagi Ahmed Abdullah, Rasedee Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. |
| title | Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. |
| title_full | Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. |
| title_fullStr | Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. |
| title_full_unstemmed | Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. |
| title_short | Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. |
| title_sort | tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques |
| url | http://psasir.upm.edu.my/id/eprint/27056/1/Tamoxifen%20drug%20loading%20solid%20lipid%20nanoparticles%20prepared%20by%20hot%20high%20pressure%20homogenization%20techniques.pdf |
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