Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice
BACKGROUND: In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown. AIM: The objective of this study was to explore the involvement of monoamine...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Verduci Editore
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29532/1/Involvement%20of%20monoaminergic%20system%20in%20the%20antidepressant-like%20effect%20of%20aqueous%20extract%20of%20Channa%20striatus%20in%20mice.pdf |
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| author | Saleem, A. M. Baharuldin, Mohamad Taufik Hidayat Mat Jais, Abdul Manan Fakurazi, Sharida Mohd Moklas, Mohamad Aris Sulaiman, Mohd Roslan Amom, Zulkhairi Basir, Rusliza |
| author_facet | Saleem, A. M. Baharuldin, Mohamad Taufik Hidayat Mat Jais, Abdul Manan Fakurazi, Sharida Mohd Moklas, Mohamad Aris Sulaiman, Mohd Roslan Amom, Zulkhairi Basir, Rusliza |
| author_sort | Saleem, A. M. |
| collection | UPM |
| description | BACKGROUND: In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown. AIM: The objective of this study was to explore the involvement of monoamines in the antidepressant-like effect of AECSF in mice. MATERIALS AND METHODS: AECSF was prepared by steaming the fillets of C. striatus. The male ICR mice were pretreated with various monoaminergic antagonists viz., p-chlorophenylalanine (100 mg/kg, i.p.), prazosin (1 mg/kg, i.p.) and yohimbine (1 mg/kg, i.p.), SCH23390 (0.05 mg/kg, s.c.) and sulpiride (50 mg/kg, i.p.) followed by treatment with AECSF and tested in tail suspension test (TST). Two-way ANOVA with Tukey test were used at p < 0.05 for significance. RESULTS: The pretreatments with p-chlorophenylalanine, prazosin and yohimbine, but not with SCH23390 and sulpiride, were able to reverse the antidepressant-like effect of AECSF in TST. CONCLUSIONS: The antidepressant-like effect of AECSF may be mediated through the serotonergic and noradrenergic systems and not through the dopaminergic system. |
| first_indexed | 2024-03-06T08:14:47Z |
| format | Article |
| id | upm.eprints-29532 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:14:47Z |
| publishDate | 2013 |
| publisher | Verduci Editore |
| record_format | dspace |
| spelling | upm.eprints-295322016-07-12T09:23:45Z http://psasir.upm.edu.my/id/eprint/29532/ Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice Saleem, A. M. Baharuldin, Mohamad Taufik Hidayat Mat Jais, Abdul Manan Fakurazi, Sharida Mohd Moklas, Mohamad Aris Sulaiman, Mohd Roslan Amom, Zulkhairi Basir, Rusliza BACKGROUND: In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown. AIM: The objective of this study was to explore the involvement of monoamines in the antidepressant-like effect of AECSF in mice. MATERIALS AND METHODS: AECSF was prepared by steaming the fillets of C. striatus. The male ICR mice were pretreated with various monoaminergic antagonists viz., p-chlorophenylalanine (100 mg/kg, i.p.), prazosin (1 mg/kg, i.p.) and yohimbine (1 mg/kg, i.p.), SCH23390 (0.05 mg/kg, s.c.) and sulpiride (50 mg/kg, i.p.) followed by treatment with AECSF and tested in tail suspension test (TST). Two-way ANOVA with Tukey test were used at p < 0.05 for significance. RESULTS: The pretreatments with p-chlorophenylalanine, prazosin and yohimbine, but not with SCH23390 and sulpiride, were able to reverse the antidepressant-like effect of AECSF in TST. CONCLUSIONS: The antidepressant-like effect of AECSF may be mediated through the serotonergic and noradrenergic systems and not through the dopaminergic system. Verduci Editore 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29532/1/Involvement%20of%20monoaminergic%20system%20in%20the%20antidepressant-like%20effect%20of%20aqueous%20extract%20of%20Channa%20striatus%20in%20mice.pdf Saleem, A. M. and Baharuldin, Mohamad Taufik Hidayat and Mat Jais, Abdul Manan and Fakurazi, Sharida and Mohd Moklas, Mohamad Aris and Sulaiman, Mohd Roslan and Amom, Zulkhairi and Basir, Rusliza (2013) Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice. European Review for Medical and Pharmacological Sciences, 17 (15). pp. 2019-2022. ISSN 1128-3602; ESSN: 2284-0729 http://www.europeanreview.org/article/4809 |
| spellingShingle | Saleem, A. M. Baharuldin, Mohamad Taufik Hidayat Mat Jais, Abdul Manan Fakurazi, Sharida Mohd Moklas, Mohamad Aris Sulaiman, Mohd Roslan Amom, Zulkhairi Basir, Rusliza Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice |
| title | Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice |
| title_full | Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice |
| title_fullStr | Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice |
| title_full_unstemmed | Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice |
| title_short | Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice |
| title_sort | involvement of monoaminergic system in the antidepressant like effect of aqueous extract of channa striatus in mice |
| url | http://psasir.upm.edu.my/id/eprint/29532/1/Involvement%20of%20monoaminergic%20system%20in%20the%20antidepressant-like%20effect%20of%20aqueous%20extract%20of%20Channa%20striatus%20in%20mice.pdf |
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