Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis
Previous studies have shown that Sox3 is expressed in nascent neuroprogenitor cells and is functionally required in mammals for development of the dorsal telencephalon and hypothalamus. However, Sox3 expression during embryonic and adult neurogenesis has not been examined in detail. Using a SOX3-spe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29599/1/Expression%20of%20the%20murine%20transcription%20factor%20SOX3%20during%20embryonic%20and%20adult%20neurogenesis.pdf |
| _version_ | 1825947543107796992 |
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| author | Rogers, Nicholas Cheah, Pike See Szareka, Eva Banerjee, Kakoli Schwartz, Jeffrey Thomas, Paul |
| author_facet | Rogers, Nicholas Cheah, Pike See Szareka, Eva Banerjee, Kakoli Schwartz, Jeffrey Thomas, Paul |
| author_sort | Rogers, Nicholas |
| collection | UPM |
| description | Previous studies have shown that Sox3 is expressed in nascent neuroprogenitor cells and is functionally required in mammals for development of the dorsal telencephalon and hypothalamus. However, Sox3 expression during embryonic and adult neurogenesis has not been examined in detail. Using a SOX3-specific antibody, we show that murine SOX3 expression is maintained throughout telencephalic neurogenesis and is restricted to progenitor cells with neuroepithelial and radial glial morphologies. We also demonstrate that SOX3 is expressed within the adult neurogenic regions and is coexpressed extensively with the neural stem cell marker SOX2 indicating that it is a lifelong marker of neuroprogenitor cells. In contrast to the telencephalon, Sox3 expression within the developing hypothalamus is upregulated in developing neurons and is maintained in a subset of differentiated hypothalamic cells through to adulthood. Together, these data show that Sox3 regulation is region-specific, consistent with it playing distinct biological roles in the dorsal telencephalon and hypothalamus. |
| first_indexed | 2024-03-06T08:14:59Z |
| format | Article |
| id | upm.eprints-29599 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:14:59Z |
| publishDate | 2013 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | upm.eprints-295992015-10-29T08:14:42Z http://psasir.upm.edu.my/id/eprint/29599/ Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis Rogers, Nicholas Cheah, Pike See Szareka, Eva Banerjee, Kakoli Schwartz, Jeffrey Thomas, Paul Previous studies have shown that Sox3 is expressed in nascent neuroprogenitor cells and is functionally required in mammals for development of the dorsal telencephalon and hypothalamus. However, Sox3 expression during embryonic and adult neurogenesis has not been examined in detail. Using a SOX3-specific antibody, we show that murine SOX3 expression is maintained throughout telencephalic neurogenesis and is restricted to progenitor cells with neuroepithelial and radial glial morphologies. We also demonstrate that SOX3 is expressed within the adult neurogenic regions and is coexpressed extensively with the neural stem cell marker SOX2 indicating that it is a lifelong marker of neuroprogenitor cells. In contrast to the telencephalon, Sox3 expression within the developing hypothalamus is upregulated in developing neurons and is maintained in a subset of differentiated hypothalamic cells through to adulthood. Together, these data show that Sox3 regulation is region-specific, consistent with it playing distinct biological roles in the dorsal telencephalon and hypothalamus. Elsevier BV 2013-10 Article NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29599/1/Expression%20of%20the%20murine%20transcription%20factor%20SOX3%20during%20embryonic%20and%20adult%20neurogenesis.pdf Rogers, Nicholas and Cheah, Pike See and Szareka, Eva and Banerjee, Kakoli and Schwartz, Jeffrey and Thomas, Paul (2013) Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. Gene Expression Patterns, 13 (7). pp. 240-248. ISSN 1567-133X; ESSN: 1872-7298 10.1016/j.gep.2013.04.004 |
| spellingShingle | Rogers, Nicholas Cheah, Pike See Szareka, Eva Banerjee, Kakoli Schwartz, Jeffrey Thomas, Paul Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis |
| title | Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis |
| title_full | Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis |
| title_fullStr | Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis |
| title_full_unstemmed | Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis |
| title_short | Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis |
| title_sort | expression of the murine transcription factor sox3 during embryonic and adult neurogenesis |
| url | http://psasir.upm.edu.my/id/eprint/29599/1/Expression%20of%20the%20murine%20transcription%20factor%20SOX3%20during%20embryonic%20and%20adult%20neurogenesis.pdf |
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