Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats
The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n = 6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200 mg/kg silymarin (pos...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Korea LLC. Health Sciences
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29681/1/Hepatoprotective%20activity%20of%20methanol%20extract%20of%20Melastoma%20malabathricum%20leaf%20in%20rats.pdf |
| _version_ | 1825947558951780352 |
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| author | Kamisan, Farah Hidayah Yahya, Farhana Ismail, Noor Aisyah Din, Syafawati Shamsahal Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Mohtarrudin, Norhafizah Husain, Hadijah Ahmad, Zuraini Zakaria, Zainul Amiruddin |
| author_facet | Kamisan, Farah Hidayah Yahya, Farhana Ismail, Noor Aisyah Din, Syafawati Shamsahal Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Mohtarrudin, Norhafizah Husain, Hadijah Ahmad, Zuraini Zakaria, Zainul Amiruddin |
| author_sort | Kamisan, Farah Hidayah |
| collection | UPM |
| description | The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n = 6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200 mg/kg silymarin (positive control), or MEMM (50, 250, or 500 mg/kg) for 7 days followed by induction of hepatotoxicity either using paracetamol or carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, MEMM exhibited a significant (p < 0.05) hepatoprotective activity against both inducers, as indicated by an improvement in the liver function test. These observations were supported by the histologic findings. In conclusion, M. malabathricum leaves possessed hepatoprotective activity, which could be linked to their phytochemical constituents and antioxidant activity; this therefore requires further in-depth studies. |
| first_indexed | 2024-03-06T08:15:14Z |
| format | Article |
| id | upm.eprints-29681 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:15:14Z |
| publishDate | 2013 |
| publisher | Elsevier Korea LLC. Health Sciences |
| record_format | dspace |
| spelling | upm.eprints-296812015-09-18T01:59:33Z http://psasir.upm.edu.my/id/eprint/29681/ Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats Kamisan, Farah Hidayah Yahya, Farhana Ismail, Noor Aisyah Din, Syafawati Shamsahal Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Mohtarrudin, Norhafizah Husain, Hadijah Ahmad, Zuraini Zakaria, Zainul Amiruddin The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n = 6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200 mg/kg silymarin (positive control), or MEMM (50, 250, or 500 mg/kg) for 7 days followed by induction of hepatotoxicity either using paracetamol or carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, MEMM exhibited a significant (p < 0.05) hepatoprotective activity against both inducers, as indicated by an improvement in the liver function test. These observations were supported by the histologic findings. In conclusion, M. malabathricum leaves possessed hepatoprotective activity, which could be linked to their phytochemical constituents and antioxidant activity; this therefore requires further in-depth studies. Elsevier Korea LLC. Health Sciences 2013-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29681/1/Hepatoprotective%20activity%20of%20methanol%20extract%20of%20Melastoma%20malabathricum%20leaf%20in%20rats.pdf Kamisan, Farah Hidayah and Yahya, Farhana and Ismail, Noor Aisyah and Din, Syafawati Shamsahal and Mamat, Siti Syariah and Zabidi, Zalina and Wan Zainulddin, Wan Noraziemah and Mohtarrudin, Norhafizah and Husain, Hadijah and Ahmad, Zuraini and Zakaria, Zainul Amiruddin (2013) Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats. Journal of Acupuncture and Meridian Studies, 6 (1). pp. 52-55. ISSN 2005-2901; ESSN: 2093-8152 10.1016/j.jams.2012.08.002 |
| spellingShingle | Kamisan, Farah Hidayah Yahya, Farhana Ismail, Noor Aisyah Din, Syafawati Shamsahal Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Mohtarrudin, Norhafizah Husain, Hadijah Ahmad, Zuraini Zakaria, Zainul Amiruddin Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats |
| title | Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats |
| title_full | Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats |
| title_fullStr | Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats |
| title_full_unstemmed | Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats |
| title_short | Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats |
| title_sort | hepatoprotective activity of methanol extract of melastoma malabathricum leaf in rats |
| url | http://psasir.upm.edu.my/id/eprint/29681/1/Hepatoprotective%20activity%20of%20methanol%20extract%20of%20Melastoma%20malabathricum%20leaf%20in%20rats.pdf |
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