Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP
The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC...
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| Format: | Article |
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Elsevier
2013
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| _version_ | 1825947564277497856 |
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| author | Lee, Ming Tatt Khalivulla, Shaik Ibrahim Akhtar, Muhammad Nadeem Lajis, Nordin Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_facet | Lee, Ming Tatt Khalivulla, Shaik Ibrahim Akhtar, Muhammad Nadeem Lajis, Nordin Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_sort | Lee, Ming Tatt |
| collection | UPM |
| description | The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC (0.03, 0.1, 0.3 and 1.0mg/kg) exhibited dose-dependent inhibition of chronic constriction injury-induced neuropathic pain in mice, when evaluated using Randall-Selitto mechanical analgesiometer. It was also demonstrated that pretreatment of naloxone (non-selective opioid receptor blocker), nor-binaltorphimine (nor-BNI, selective κ-opioid receptor blocker), but not β-funaltrexamine (β-FN, selective μ-opioid receptor blocker) and naltrindole hydrochloride (NTI, selective δ-opioid receptor blocker), reversed the anti-nociceptive effect of BHMC. In addition, the analgesic effect of BHMC was also reverted by pretreatment of 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ, soluble guanosyl cyclase blocker) and glibenclamide (ATP-sensitive potassium channel blocker) but not Nω-nitro-l-arginine (l-NAME, a nitric oxide synthase blocker). Taken together, the present study demonstrated that the systemic administration of BHMC attenuated chronic constriction, injury-induced neuropathic pain. We also suggested that the possible mechanisms include κ-opioid receptor activation and nitric oxide-independent cyclic guanosine monophosphate activation of ATP-sensitive potassium channel opening. |
| first_indexed | 2024-03-06T08:15:19Z |
| format | Article |
| id | upm.eprints-29708 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T08:15:19Z |
| publishDate | 2013 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-297082015-12-08T01:22:28Z http://psasir.upm.edu.my/id/eprint/29708/ Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP Lee, Ming Tatt Khalivulla, Shaik Ibrahim Akhtar, Muhammad Nadeem Lajis, Nordin Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC (0.03, 0.1, 0.3 and 1.0mg/kg) exhibited dose-dependent inhibition of chronic constriction injury-induced neuropathic pain in mice, when evaluated using Randall-Selitto mechanical analgesiometer. It was also demonstrated that pretreatment of naloxone (non-selective opioid receptor blocker), nor-binaltorphimine (nor-BNI, selective κ-opioid receptor blocker), but not β-funaltrexamine (β-FN, selective μ-opioid receptor blocker) and naltrindole hydrochloride (NTI, selective δ-opioid receptor blocker), reversed the anti-nociceptive effect of BHMC. In addition, the analgesic effect of BHMC was also reverted by pretreatment of 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ, soluble guanosyl cyclase blocker) and glibenclamide (ATP-sensitive potassium channel blocker) but not Nω-nitro-l-arginine (l-NAME, a nitric oxide synthase blocker). Taken together, the present study demonstrated that the systemic administration of BHMC attenuated chronic constriction, injury-induced neuropathic pain. We also suggested that the possible mechanisms include κ-opioid receptor activation and nitric oxide-independent cyclic guanosine monophosphate activation of ATP-sensitive potassium channel opening. Elsevier 2013-12 Article PeerReviewed Lee, Ming Tatt and Khalivulla, Shaik Ibrahim and Akhtar, Muhammad Nadeem and Lajis, Nordin and Perimal, Enoch Kumar and Omar Farouk, Ahmad Akira and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2013) Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP. Pharmacology Biochemistry and Behavior, 114-115. pp. 58-63. ISSN 0091-3057; ESSN: 1873-5177 10.1016/j.pbb.2013.10.019 |
| spellingShingle | Lee, Ming Tatt Khalivulla, Shaik Ibrahim Akhtar, Muhammad Nadeem Lajis, Nordin Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP |
| title | Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP |
| title_full | Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP |
| title_fullStr | Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP |
| title_full_unstemmed | Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP |
| title_short | Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP |
| title_sort | anti hyperalgesic effect of a benzilidine cyclohexanone analogue on a mouse model of chronic constriction injury induced neuropathic pain participation of the κ opioid receptor and katp |
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