Eradication of malaria through genetic engineering: the current situation

Malaria is an intra-cellular parasitic protozoon responsible for millions of deaths annually. Host and parasite genetic factors are crucial in affecting susceptibility to malaria and progression of the disease. Recent increased deployment of vector controls and new artemisinin combination therapies...

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Main Authors: Chong, Wing Chui, Basir, Rusliza, Yam, Mun Fei
Format: Article
Language:English
Published: Elsevier 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29712/1/Eradication%20of%20malaria%20through%20genetic%20engineering.pdf
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author Chong, Wing Chui
Basir, Rusliza
Yam, Mun Fei
author_facet Chong, Wing Chui
Basir, Rusliza
Yam, Mun Fei
author_sort Chong, Wing Chui
collection UPM
description Malaria is an intra-cellular parasitic protozoon responsible for millions of deaths annually. Host and parasite genetic factors are crucial in affecting susceptibility to malaria and progression of the disease. Recent increased deployment of vector controls and new artemisinin combination therapies have dramatically reduced the mortality and morbidity of malaria worldwide. However, the gradual emergence of parasite and mosquito resistance has raised alarm regarding the effectiveness of current artemisinin-based therapies. In this review, mechanisms of anti-malarial drug resistance in the Plasmodium parasite and new genetically engineered tools of research priorities are discussed. The complexity of the parasite lifecycle demands novel interventions to achieve global eradication. However, turning laboratory discovered transgenic interventions into functional products entails multiple experimental phases in addition to ethical and safety hurdles. Uncertainty over the regulatory status and public acceptance further discourage the implementation of genetically modified organisms.
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spelling upm.eprints-297122017-10-27T08:54:58Z http://psasir.upm.edu.my/id/eprint/29712/ Eradication of malaria through genetic engineering: the current situation Chong, Wing Chui Basir, Rusliza Yam, Mun Fei Malaria is an intra-cellular parasitic protozoon responsible for millions of deaths annually. Host and parasite genetic factors are crucial in affecting susceptibility to malaria and progression of the disease. Recent increased deployment of vector controls and new artemisinin combination therapies have dramatically reduced the mortality and morbidity of malaria worldwide. However, the gradual emergence of parasite and mosquito resistance has raised alarm regarding the effectiveness of current artemisinin-based therapies. In this review, mechanisms of anti-malarial drug resistance in the Plasmodium parasite and new genetically engineered tools of research priorities are discussed. The complexity of the parasite lifecycle demands novel interventions to achieve global eradication. However, turning laboratory discovered transgenic interventions into functional products entails multiple experimental phases in addition to ethical and safety hurdles. Uncertainty over the regulatory status and public acceptance further discourage the implementation of genetically modified organisms. Elsevier 2013-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29712/1/Eradication%20of%20malaria%20through%20genetic%20engineering.pdf Chong, Wing Chui and Basir, Rusliza and Yam, Mun Fei (2013) Eradication of malaria through genetic engineering: the current situation. Asian Pacific Journal of Tropical Medicine, 6 (2). pp. 85-94. ISSN 1995-7645 10.1016/S1995-7645(13)60001-2
spellingShingle Chong, Wing Chui
Basir, Rusliza
Yam, Mun Fei
Eradication of malaria through genetic engineering: the current situation
title Eradication of malaria through genetic engineering: the current situation
title_full Eradication of malaria through genetic engineering: the current situation
title_fullStr Eradication of malaria through genetic engineering: the current situation
title_full_unstemmed Eradication of malaria through genetic engineering: the current situation
title_short Eradication of malaria through genetic engineering: the current situation
title_sort eradication of malaria through genetic engineering the current situation
url http://psasir.upm.edu.my/id/eprint/29712/1/Eradication%20of%20malaria%20through%20genetic%20engineering.pdf
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