Xanthones from Calophyllum gracilipes and their cytotoxic activity.
Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigm...
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| Format: | Article |
| Language: | English |
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Universiti Kebangsaan Malaysia
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29812/1/Xanthones%20from%20Calophyllum%20gracilipes%20and%20their%20cytotoxic%20activity.pdf |
| _version_ | 1825947584811761664 |
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| author | Mad Nasir, Nadiah Rahmani, Mawardi Shaari, Khozirah Kassim, Nur Kartinee Go, Rusea Stanslas, Johnson Jeyaraj, Ethel Jeyaseela |
| author_facet | Mad Nasir, Nadiah Rahmani, Mawardi Shaari, Khozirah Kassim, Nur Kartinee Go, Rusea Stanslas, Johnson Jeyaraj, Ethel Jeyaseela |
| author_sort | Mad Nasir, Nadiah |
| collection | UPM |
| description | Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00μM. |
| first_indexed | 2024-03-06T08:15:38Z |
| format | Article |
| id | upm.eprints-29812 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:15:38Z |
| publishDate | 2013 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | upm.eprints-298122015-10-07T06:24:51Z http://psasir.upm.edu.my/id/eprint/29812/ Xanthones from Calophyllum gracilipes and their cytotoxic activity. Mad Nasir, Nadiah Rahmani, Mawardi Shaari, Khozirah Kassim, Nur Kartinee Go, Rusea Stanslas, Johnson Jeyaraj, Ethel Jeyaseela Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00μM. Universiti Kebangsaan Malaysia 2013-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29812/1/Xanthones%20from%20Calophyllum%20gracilipes%20and%20their%20cytotoxic%20activity.pdf Mad Nasir, Nadiah and Rahmani, Mawardi and Shaari, Khozirah and Kassim, Nur Kartinee and Go, Rusea and Stanslas, Johnson and Jeyaraj, Ethel Jeyaseela (2013) Xanthones from Calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana, 42 (9). pp. 1261-1266. ISSN 0026-6039 http://www.ukm.my/jsm/english_journals/vol42num9_2013/contentsVol42num9_2013.html |
| spellingShingle | Mad Nasir, Nadiah Rahmani, Mawardi Shaari, Khozirah Kassim, Nur Kartinee Go, Rusea Stanslas, Johnson Jeyaraj, Ethel Jeyaseela Xanthones from Calophyllum gracilipes and their cytotoxic activity. |
| title | Xanthones from Calophyllum gracilipes and their cytotoxic activity. |
| title_full | Xanthones from Calophyllum gracilipes and their cytotoxic activity. |
| title_fullStr | Xanthones from Calophyllum gracilipes and their cytotoxic activity. |
| title_full_unstemmed | Xanthones from Calophyllum gracilipes and their cytotoxic activity. |
| title_short | Xanthones from Calophyllum gracilipes and their cytotoxic activity. |
| title_sort | xanthones from calophyllum gracilipes and their cytotoxic activity |
| url | http://psasir.upm.edu.my/id/eprint/29812/1/Xanthones%20from%20Calophyllum%20gracilipes%20and%20their%20cytotoxic%20activity.pdf |
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