In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer
Drug delivery systems are designed to achieve drug therapeutic index and enhance the efficacy of controlled drug release targeting with specificity and selectivity by successful delivery of therapeutic agents at the desired sites without affecting the non-diseased neighbouring cells or tissues. In t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/29862/1/In%20vitro%20delivery%20and%20controlled%20release%20of%20doxorubicin%20for%20targeting%20osteosarcoma%20bone%20cancer.pdf |
| _version_ | 1825947594451320832 |
|---|---|
| author | Kamba, Shafiu Abdullahi Ismail, Maznah Hussein Al-Ali, Samer Hasan Tengku Ibrahim, Tengku Azmi Abu Bakar @ Zakaria, Md Zuki |
| author_facet | Kamba, Shafiu Abdullahi Ismail, Maznah Hussein Al-Ali, Samer Hasan Tengku Ibrahim, Tengku Azmi Abu Bakar @ Zakaria, Md Zuki |
| author_sort | Kamba, Shafiu Abdullahi |
| collection | UPM |
| description | Drug delivery systems are designed to achieve drug therapeutic index and enhance the efficacy of controlled drug release targeting with specificity and selectivity by successful delivery of therapeutic agents at the desired sites without affecting the non-diseased neighbouring cells or tissues. In this research, we developed and demonstrated a bio-based calcium carbonate nanocrystals carrier that can be loaded with anticancer drug and selectively deliver it to cancer cells with high specificity by achieving the effective osteosarcoma cancer cell death without inducing specific toxicity. The results showed pH sensitivity of the controlled release characteristics of the drug at normal physiological pH 7.4 with approximately 80% released within 1,200 min but when exposed pH 4.8 the corresponding 80% was released in 50 min. This study showed that the DOX-loaded CaCO3 nanocrystals have promising applications in delivery of anticancer drugs. |
| first_indexed | 2024-03-06T08:15:47Z |
| format | Article |
| id | upm.eprints-29862 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:15:47Z |
| publishDate | 2013 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-298622016-11-21T02:27:56Z http://psasir.upm.edu.my/id/eprint/29862/ In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer Kamba, Shafiu Abdullahi Ismail, Maznah Hussein Al-Ali, Samer Hasan Tengku Ibrahim, Tengku Azmi Abu Bakar @ Zakaria, Md Zuki Drug delivery systems are designed to achieve drug therapeutic index and enhance the efficacy of controlled drug release targeting with specificity and selectivity by successful delivery of therapeutic agents at the desired sites without affecting the non-diseased neighbouring cells or tissues. In this research, we developed and demonstrated a bio-based calcium carbonate nanocrystals carrier that can be loaded with anticancer drug and selectively deliver it to cancer cells with high specificity by achieving the effective osteosarcoma cancer cell death without inducing specific toxicity. The results showed pH sensitivity of the controlled release characteristics of the drug at normal physiological pH 7.4 with approximately 80% released within 1,200 min but when exposed pH 4.8 the corresponding 80% was released in 50 min. This study showed that the DOX-loaded CaCO3 nanocrystals have promising applications in delivery of anticancer drugs. MDPI 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29862/1/In%20vitro%20delivery%20and%20controlled%20release%20of%20doxorubicin%20for%20targeting%20osteosarcoma%20bone%20cancer.pdf Kamba, Shafiu Abdullahi and Ismail, Maznah and Hussein Al-Ali, Samer Hasan and Tengku Ibrahim, Tengku Azmi and Abu Bakar @ Zakaria, Md Zuki (2013) In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer. Molecules, 18 (9). pp. 10580-10598. ISSN 1420-3049 http://www.mdpi.com/1420-3049/18/9/10580 10.3390/molecules180910580 |
| spellingShingle | Kamba, Shafiu Abdullahi Ismail, Maznah Hussein Al-Ali, Samer Hasan Tengku Ibrahim, Tengku Azmi Abu Bakar @ Zakaria, Md Zuki In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer |
| title | In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer |
| title_full | In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer |
| title_fullStr | In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer |
| title_full_unstemmed | In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer |
| title_short | In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer |
| title_sort | in vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer |
| url | http://psasir.upm.edu.my/id/eprint/29862/1/In%20vitro%20delivery%20and%20controlled%20release%20of%20doxorubicin%20for%20targeting%20osteosarcoma%20bone%20cancer.pdf |
| work_keys_str_mv | AT kambashafiuabdullahi invitrodeliveryandcontrolledreleaseofdoxorubicinfortargetingosteosarcomabonecancer AT ismailmaznah invitrodeliveryandcontrolledreleaseofdoxorubicinfortargetingosteosarcomabonecancer AT husseinalalisamerhasan invitrodeliveryandcontrolledreleaseofdoxorubicinfortargetingosteosarcomabonecancer AT tengkuibrahimtengkuazmi invitrodeliveryandcontrolledreleaseofdoxorubicinfortargetingosteosarcomabonecancer AT abubakarzakariamdzuki invitrodeliveryandcontrolledreleaseofdoxorubicinfortargetingosteosarcomabonecancer |