Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats
A trial was conducted to compare the cellular responses in the respiratory tract in intranasal vaccination against caprine Peste des petits ruminant lineage 1 variant virus infection with intramuscular and subcutaneous vaccinations in order to elucidate the mechanism of the protection. Twenty four...
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| Format: | Article |
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Sociedad Chilena de Anatomía
2013
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| _version_ | 1796971627417698304 |
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| author | Ezeasor, Chukwunonso Kenechukwu Emikpe, Benjamin Obukowho Mohd Yusoff, Sabri Afusat, Jagun Anosa, Victor O. |
| author_facet | Ezeasor, Chukwunonso Kenechukwu Emikpe, Benjamin Obukowho Mohd Yusoff, Sabri Afusat, Jagun Anosa, Victor O. |
| author_sort | Ezeasor, Chukwunonso Kenechukwu |
| collection | UPM |
| description | A trial was conducted to compare the cellular responses in the respiratory tract in intranasal vaccination against caprine Peste des petits ruminant lineage 1 variant virus infection with intramuscular and subcutaneous vaccinations in order to elucidate
the mechanism of the protection. Twenty four goats were divided into four equal groups. Group 1 was vaccinated intranasaly, group 2 was vaccinated subcutaneously, and group 3 intramuscularly, while Group 4 was the unvaccinated control group. In each group the vaccinations were carried out once. All goats were challenged intratrachealy with PPR virus at a concentration of 106.5 TCID50 two weeks after
vaccination and were euthanised 21 days after the challenge. The bronchoalveolar lavage differential count, bronchial associated lymphoid tissue (BALT) responses were measured using standard techniques. Descriptive Statistics and ANOVA was employed and significance was
at p < 0.05. The exposure also resulted into significant increase in the number and size of BALT as well as the number of lymphocytes in BALT. This study showed the mechanism of the protective effect of intranasal vaccination of PPR vaccine observed with the strong
mucosal and defensive cellular responses in the respiratory tract observed than the subcutaneous and intramuscular routes. |
| first_indexed | 2024-03-06T08:15:48Z |
| format | Article |
| id | upm.eprints-29870 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T08:15:48Z |
| publishDate | 2013 |
| publisher | Sociedad Chilena de Anatomía |
| record_format | dspace |
| spelling | upm.eprints-298702016-01-20T01:48:47Z http://psasir.upm.edu.my/id/eprint/29870/ Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats Ezeasor, Chukwunonso Kenechukwu Emikpe, Benjamin Obukowho Mohd Yusoff, Sabri Afusat, Jagun Anosa, Victor O. A trial was conducted to compare the cellular responses in the respiratory tract in intranasal vaccination against caprine Peste des petits ruminant lineage 1 variant virus infection with intramuscular and subcutaneous vaccinations in order to elucidate the mechanism of the protection. Twenty four goats were divided into four equal groups. Group 1 was vaccinated intranasaly, group 2 was vaccinated subcutaneously, and group 3 intramuscularly, while Group 4 was the unvaccinated control group. In each group the vaccinations were carried out once. All goats were challenged intratrachealy with PPR virus at a concentration of 106.5 TCID50 two weeks after vaccination and were euthanised 21 days after the challenge. The bronchoalveolar lavage differential count, bronchial associated lymphoid tissue (BALT) responses were measured using standard techniques. Descriptive Statistics and ANOVA was employed and significance was at p < 0.05. The exposure also resulted into significant increase in the number and size of BALT as well as the number of lymphocytes in BALT. This study showed the mechanism of the protective effect of intranasal vaccination of PPR vaccine observed with the strong mucosal and defensive cellular responses in the respiratory tract observed than the subcutaneous and intramuscular routes. Sociedad Chilena de Anatomía 2013-09-24 Article PeerReviewed Ezeasor, Chukwunonso Kenechukwu and Emikpe, Benjamin Obukowho and Mohd Yusoff, Sabri and Afusat, Jagun and Anosa, Victor O. (2013) Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats. International Journal of Morphology, 31 (2). pp. 687-692. ISSN 0717-9367; ESSN: 0717-9502 http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-95022013000200056&lng=en&nrm=iso&tlng=en |
| spellingShingle | Ezeasor, Chukwunonso Kenechukwu Emikpe, Benjamin Obukowho Mohd Yusoff, Sabri Afusat, Jagun Anosa, Victor O. Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats |
| title | Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats |
| title_full | Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats |
| title_fullStr | Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats |
| title_full_unstemmed | Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats |
| title_short | Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats |
| title_sort | cellular responses in the respiratory tract following intranasal administration of peste des petits ruminant vaccine in goats |
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